Evidence map›Paper›PMID 37535739›Full record

ArticleScience (New York, N.Y.)2023

The genetic legacy of African Americans from Catoctin Furnace.

Éadaoin Harney, Steven Micheletti, Karin S Bruwelheide, William A Freyman, Katarzyna Bryc, Ali Akbari, Ethan Jewett, Elizabeth Comer, Henry Louis Gates, Linda Heywood and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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  7. Review
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  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Éadaoin Harney23andMe, Inc., Sunnyvale, CA 94043, USA.ORCID 0000-0001-9385-7297
Steven Micheletti23andMe, Inc., Sunnyvale, CA 94043, USA.ORCID 0000-0002-3842-0946
Karin S BruwelheideDepartment of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560, USA.
William A Freyman23andMe, Inc., Sunnyvale, CA 94043, USA.ORCID 0000-0002-3463-2044
Katarzyna Bryc23andMe, Inc., Sunnyvale, CA 94043, USA.ORCID 0009-0006-7659-1056
Ali AkbariDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-5000-5876
Ethan Jewett23andMe, Inc., Sunnyvale, CA 94043, USA.
Elizabeth ComerCatoctin Furnace Historical Society, Thurmont, MD 21788, USA.
Henry Louis GatesHutchins Center for African and African American Research, Harvard University, Cambridge, MA 02138, USA.ORCID 0009-0000-2347-5912
Linda HeywoodAfrican American and Black Diaspora Studies, Department of History, Boston University, Brookline, MA 02446, USA.ORCID 0009-0001-5871-9267
John ThorntonAfrican American and Black Diaspora Studies, Department of History, Boston University, Brookline, MA 02446, USA.ORCID 0000-0001-8760-2634
Roslyn Curry23andMe, Inc., Sunnyvale, CA 94043, USA.
Samantha Ancona Esselmann23andMe, Inc., Sunnyvale, CA 94043, USA.ORCID 0009-0001-0169-8899
Kathryn G BarcaDepartment of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560, USA.ORCID 0000-0001-6487-7926
Jakob SedigDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0001-6642-7734
Kendra SirakDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-2347-3479
Iñigo OlaldeDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-2660-6807
Nicole AdamskiDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6486-9416
Rebecca BernardosDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-4625-3727
Nasreen BroomandkhoshbachtDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5350-1608
Matthew FerryDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7319-0085
Lijun QiuDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-4377-8659
Kristin StewardsonDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
J Noah WorkmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0921-1803
Fatma ZalzalaDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8981-1277
Shop MallickDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Adam MiccoDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6016-964X
Matthew MahDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8987-6436
Zhao ZhangDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7562-7559
23andMe Research Team†
Nadin RohlandDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Joanna L Mountain *23andMe, Inc., Sunnyvale, CA 94043, USA.ORCID 0000-0002-5984-5521
Douglas W Owsley *Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560, USA.ORCID 0000-0001-5071-6910
David Reich *Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-7037-5292
23andMe Research Team

Funding

Solving ascertainment bias in ancient DNA using Ultima Genomics sequencingR01HG012287 · NHGRI · HARVARD MEDICAL SCHOOL · PI REICH, DAVID E · 2021 to 2025
$2.7M
Scalable methods for the characterization and analysis of families in large genomic datasetsR35GM133805 · NIGMS · CORNELL UNIVERSITY · PI WILLIAMS, AMY LYNNE · 2019 to 2023
$1.6M
Howard Hughes Medical InstituteNHGRI NIH HHS R01 HG012287NIGMS NIH HHS R35 GM133805
6 · The paper itself

Abstract

Few African Americans have been able to trace family lineages back to ancestors who died before the 1870 United States Census, the first in which all Black people were listed by name. We analyzed 27 individuals from Maryland's Catoctin Furnace African American Cemetery (1774-1850), identifying 41,799 genetic relatives among consenting research participants in 23andMe, Inc.'s genetic database. One of the highest concentrations of close relatives is in Maryland, suggesting that descendants of the Catoctin individuals remain in the area. We find that many of the Catoctin individuals derived African ancestry from the Wolof or Kongo groups and European ancestry from Great Britain and Ireland. This study demonstrates the power of joint analysis of historical DNA and large datasets generated through direct-to-consumer ancestry testing.

Indexed as

Black or African AmericanDatabases, GeneticHumansIrelandMarylandSequence Analysis, DNAUnited States

Identifiers

PMID37535739
PMCPMC10958645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.