Evidence map›Paper›PMID 37535564›Full record

Trial reportPloS one2023

Evaluating the ability of an artificial-intelligence cloud-based platform designed to provide information prior to locoregional therapy for breast cancer in improving patient's satisfaction with therapy: The CINDERELLA trial.

Orit Kaidar-Person, Marilia Antunes, Jaime S Cardoso, Oriana Ciani, Helena Cruz, Rosa Di Micco, Oreste D Gentilini, Tiago Gonçalves, Pedro Gouveia, Jörg Heil and 15 more

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Orit Kaidar-PersonBreast Cancer Radiation Therapy Unit, Sheba Medical Center, Ramat Gan, Israel.ORCID 0000-0003-4023-1869
Marilia AntunesFaculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.ORCID 0000-0002-1257-2829
Jaime S CardosoCenter for Research on Health and Social Care Management (CERGAS), SDA Bocconi University, Milan, Italy.
Oriana CianiInstitute for Systems and Computer Engineering, Technology and Science (INESC TEC), Porto, Portugal.ORCID 0000-0002-3607-0508
Helena CruzFaculty of Engineering, University of Porto (FEUP), Porto, Portugal.
Rosa Di MiccoBreast Surgery Unit, San Raffaele University and Research Hospital, Milano, Italy.ORCID 0000-0002-2575-8729
Oreste D GentiliniBreast Surgery Unit, San Raffaele University and Research Hospital, Milano, Italy.
Tiago GonçalvesCenter for Research on Health and Social Care Management (CERGAS), SDA Bocconi University, Milan, Italy.ORCID 0000-0003-4744-9174
Pedro GouveiaFaculty of Engineering, University of Porto (FEUP), Porto, Portugal.
Jörg HeilInstituto Universitario de Lisboa (ISCTE), Lisboa, Portugal.
Pawel KabataCANKADO GmbH, Ottobrunn, Germany.
Daniela LopesFaculty of Engineering, University of Porto (FEUP), Porto, Portugal.
Marta MartinhoFaculty of Engineering, University of Porto (FEUP), Porto, Portugal.
Henrique MartinsFaculty of Engineering, University of Porto (FEUP), Porto, Portugal.
Carlos MaviosoFaculty of Engineering, University of Porto (FEUP), Porto, Portugal.
Martin MikaDepartment of Surgical Oncology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Helena MontenegroCenter for Research on Health and Social Care Management (CERGAS), SDA Bocconi University, Milan, Italy.
Helder P OliveiraCenter for Research on Health and Social Care Management (CERGAS), SDA Bocconi University, Milan, Italy.
André PfobInstituto Universitario de Lisboa (ISCTE), Lisboa, Portugal.
Nicole RotmenszBreast Surgery Unit, San Raffaele University and Research Hospital, Milano, Italy.
Timo SchinkötheDepartment of Surgical Oncology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Giovani SilvaFaculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.
Rosana TarriconeInstitute for Systems and Computer Engineering, Technology and Science (INESC TEC), Porto, Portugal.
Maria-Joao CardosoFaculty of Engineering, University of Porto (FEUP), Porto, Portugal.ORCID 0000-0002-8137-3700
CINDERELLA Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer therapy improved significantly, allowing for different surgical approaches for the same disease stage, therefore offering patients different aesthetic outcomes with similar locoregional control. The purpose of the CINDERELLA trial is to evaluate an artificial-intelligence (AI) cloud-based platform (CINDERELLA platform) vs the standard approach for patient education prior to therapy.

methodsA prospective randomized international multicentre trial comparing two methods for patient education prior to therapy. After institutional ethics approval and a written informed consent, patients planned for locoregional treatment will be randomized to the intervention (CINDERELLA platform) or controls. The patients in the intervention arm will use the newly designed web-application (CINDERELLA platform, CINDERELLA APProach) to access the information related to surgery and/or radiotherapy. Using an AI system, the platform will provide the patient with a picture of her own aesthetic outcome resulting from the surgical procedure she chooses, and an objective evaluation of this aesthetic outcome (e.g., good/fair). The control group will have access to the standard approach. The primary objectives of the trial will be i) to examine the differences between the treatment arms with regards to patients' pre-treatment expectations and the final aesthetic outcomes and ii) in the experimental arm only, the agreement of the pre-treatment AI-evaluation (output) and patient's post-therapy self-evaluation. DISCUSSION: The project aims to develop an easy-to-use cost-effective AI-powered tool that improves shared decision-making processes. We assume that the CINDERELLA APProach will lead to higher satisfaction, better psychosocial status, and wellbeing of breast cancer patients, and reduce the need for additional surgeries to improve aesthetic outcome.

Indexed as

Artificial IntelligenceBreast NeoplasmsCloud ComputingFemaleHumansIntelligencePatient SatisfactionProspective Studies

Identifiers

PMID37535564
PMCPMC10399739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.