ArticleNeuropsychology2024
Multiple sclerosis is associated with differences in semantic memory structure.
Article in Neuropsychology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Reduced age differences in semantic memory networks: Evidence from semantically diverse free associations.Neuropsychologia · 2026Article
- Phonological networks remain intact in multiple sclerosis.Neuropsychology · 2026Article
- Lexical retrieval in fluent and nonfluent aphasia: a network analysis of verbal fluency data.Frontiers in human neuroscience · 2025Article
- Multiple sclerosis is associated with differences in semantic memory structure.Neuropsychology · 2024Article
- Semantic networks in relapsing-remitting multiple sclerosis exhibit reduced efficiency, interconnectivity, and flexibility.Multiple sclerosis journal - experimental, translational and clinicalArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveAlthough language is often considered to be largely intact in multiple sclerosis (MS), word-finding difficulties are a common complaint. Recent work suggests that declines in language are not solely the result of motoric and cognitive slowing that is most strongly associated with MS. Network science approaches have been effectively used to examine network structure as it relates to clinical conditions, aging, and language. The present study utilizes a network science approach to investigate whether individuals with MS exhibit less interconnected and resilient semantic networks compared to age-matched neurotypical peers.
methodWe used semantic fluency data from 89 participants with MS and 88 neurotypical participants to estimate and analyze the semantic network structure for each participant group. Additionally, we conducted a percolation analysis to examine the resilience of each network.
resultsNetwork measures showed that individuals with MS had lower local and global clustering coefficients, longer average shortest path lengths, and higher modularity values compared to neurotypical peers. Small-worldness, network portrait divergence measures, and community detection analyses were consistent with these results and indicated that macroscopic properties of the two networks differed and that the semantic network for individuals with MS was more fractured than the neurotypical peer network. Moreover, a spreading activation simulation and percolation analysis suggested that the semantic networks of individuals with MS are less flexible and activation degrades faster than those of age-matched neurotypical participants.
conclusionsThese differing semantic network structures suggest that language retrieval difficulties in MS partially result from decline in language-specific factors. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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