Evidence map›Paper›PMID 37535256›Full record

ArticleEuropean child & adolescent psychiatry2024

Children with a history of both maternal immune activation and prematurity are not at increased risk of ADHD symptoms.

Pierre Ellul, Solène Wallez, Eric Acquaviva, Michelle Rosenzwajg, David Klatzmann, Richard Delorme, Maria Melchior

Abstract read
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In one paragraph

Article in European child & adolescent psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Maternal immune activation in mice recapitulates features of attention-deficit/hyperactivity disorder (ADHD) in susceptible offspring.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pierre Ellul *Child and Adolescent Psychiatry Department, Robert Debré Hospital, University of Paris Cité, Paris, France.
Solène Wallez *Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, ERES, 75012, Paris, France.
Eric AcquavivaChild and Adolescent Psychiatry Department, Robert Debré Hospital, University of Paris Cité, Paris, France.
Michelle RosenzwajgImmunology, Immunopathology, Immunotherapy, INSERM U959, Pitié Salpétrière Hospital, Sorbonne University, Paris, France.
David KlatzmannImmunology, Immunopathology, Immunotherapy, INSERM U959, Pitié Salpétrière Hospital, Sorbonne University, Paris, France.
Richard DelormeChild and Adolescent Psychiatry Department, Robert Debré Hospital, University of Paris Cité, Paris, France.
Maria MelchiorSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, ERES, 75012, Paris, France. maria.melchior@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal autoimmune diseases (AID) are risk factors for Attention Deficit Hyperactivity Disorder (ADHD). Animal studies suggest that maternal immune activation (MIA) is a disease primer for ADHD, with second environmental factor precipitating the onset of the disease. Prematurity is also a major risk factor for ADHD. In this study, we sought to explore the interaction between parental AID and prematurity on ADHD risk in a community sample. Children of AID parents born prematurely appeared at increased odds of ADHD but these two risk factors do not appear to be additive (OR 1.39 [95 CI 0.75; 2.46]). Longitudinal studies with larger numbers of participants are needed.

Indexed as

Attention Deficit Disorder with HyperactivityAdultAutoimmune DiseasesChildFemaleHumansInfant, NewbornInfant, PrematureMalePregnancyPremature BirthPrenatal Exposure Delayed EffectsRisk FactorsEpidemiologyNeurodevelopmentNeuroimmunologyTwo-hit model

Identifiers

PMID37535256

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.