Evidence map›Paper›PMID 37535157›Full record

ArticleEuropean radiology2024

Deep convolutional neural network for differentiating between sarcoidosis and lymphoma based on [

Hikaru Aoki, Yasunari Miyazaki, Tatsuhiko Anzai, Kota Yokoyama, Junichi Tsuchiya, Tsuyoshi Shirai, Sho Shibata, Rie Sakakibara, Takahiro Mitsumura, Takayuki Honda and 8 more

Abstract read
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In one paragraph

Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Diagnostic Value ofTechnology in cancer research & treatment
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Hikaru AokiDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Yasunari MiyazakiDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan. miyazaki.pilm@tmd.ac.jp.ORCID http://orcid.org/0000-0002-9073-9815
Tatsuhiko AnzaiDepartment of Biostatistics, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Kota YokoyamaDepartment of Diagnostic Radiology and Nuclear Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Junichi TsuchiyaDepartment of Diagnostic Radiology and Nuclear Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tsuyoshi ShiraiDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Sho ShibataDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Rie SakakibaraDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Takahiro MitsumuraDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Takayuki HondaDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Haruhiko FurusawaDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Tsukasa OkamotoDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Tomoya TateishiDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Meiyo TamaokaDepartment of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo, Bunkyo-ku, 113-8510, Japan.
Masahide YamamotoDepartment of Hematological Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Kunihiko TakahashiDepartment of Biostatistics, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Ukihide TateishiDepartment of Diagnostic Radiology and Nuclear Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tetsuo YamaguchiDepartment of Human Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
Tokyo Medical and Dental University · JP

Funding

the Diffuse Lung Diseases Research Group from the Ministry of Health, Labor and Welfare, Japan 20FC1033
6 · The paper itself

Abstract

objectivesTo compare the [

methodsWe retrospectively collected data on consecutive patients newly diagnosed with sarcoidosis and ML who underwent [

resultsA total of 56 patients with sarcoidosis and 62 patients with ML were included. Patients with sarcoidosis had more prominent FDG accumulation in the mediastinal lymph nodes and lung lesions, while those with ML had more prominent accumulation in the cervical lymph nodes (all p < 0.001). For the mediastinal lymph nodes, sarcoidosis patients had significant FDG accumulation in the level 2, 4, 7, and 10 lymph nodes (all p < 0.01). Otherwise, the accumulation in ML patients tended to be in the level 1 lymph nodes (p = 0.08). The CNN model using frontal and lateral MIP images achieved an average accuracy of 0.890 (95% CI: 0.804-0.977), a sensitivity of 0.898 (95% CI: 0.782-1.000), a specificity of 0.907 (95% CI: 0.799-1.000), and an area under the curve of 0.963 (95% CI: 0.899-1.000). Grad-CAM showed that the model focused on the sites of abnormal FDG accumulation.

conclusionsCNN models based on differences in FDG accumulation sites archive high performance in differentiating between sarcoidosis and ML. CLINICAL RELEVANCE STATEMENT: We developed a CNN model using MIP images of [ KEY POINTS: • There are differences in FDG distribution when comparing whole-body [

Indexed as

LymphomaSarcoidosisFluorodeoxyglucose F18HumansNeural Networks, ComputerPositron Emission Tomography Computed TomographyRetrospective StudiesFluorodeoxyglucose F18[18F]FDG PET/CTConvolutional neural networkDeep learningMalignant lymphomaSarcoidosis

Identifiers

PMID37535157
OpenAlexW4385514957

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.