Evidence map›Paper›PMID 37535133›Full record

ArticleArchives of gynecology and obstetrics2024

Can immunohistochemistry improve the pathological diagnosis of placenta accreta spectrum (PAS) disorders?

Lorena Losi, Laura Botticelli, Luciano Mancini, Rosa Negro, Esther Hanspeter, Eva Dematté, Giovanni Grandi, Fabio Facchinetti, Micaela Veneziano, Claudia Malagoli and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lorena LosiDepartment of Life Sciences, Unit of Pathology, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy. lorena.losi@unimore.it.ORCID http://orcid.org/0000-0002-8483-3936
Laura BotticelliUnit of Pathology, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Luciano ManciniUnit of Pathology, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Rosa NegroService of Pathology of Azienda Ospedaliera of Bolzano, Bolzano, Italy.
Esther HanspeterService of Pathology of Azienda Ospedaliera of Bolzano, Bolzano, Italy.
Eva DemattéService of Pathology of Azienda Ospedaliera of Bolzano, Bolzano, Italy.
Giovanni GrandiDepartment of Medical and Surgical Sciences for Mother, Child and Adult, Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Fabio FacchinettiDepartment of Medical and Surgical Sciences for Mother, Child and Adult, Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Micaela VenezianoObstetrics and Gynecology Unit, Bolzano Hospital, Bolzano, Italy.
Claudia MalagoliUnit of Pathology, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Meris MasiniDepartment of Medical and Surgical Sciences for Mother, Child and Adult, Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Luca FabbianiDepartment of Medical and Surgical Sciences for Mother, Child and Adult, Unit of Pathology, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Francesco RivasiDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe term of placenta accreta spectrum (PAS) disorder includes all grades of abnormal placentation. It is crucial for pathologist provide standardized diagnostic assessment to evaluate the outcome of management strategies. Moreover, a correct and safe diagnosis is useful in the medico-legal field when it becomes difficult for the gynecologist to demonstrate the suitability and legitimacy of demolitive treatment. The purposes of our study were: (1) to assess histopathologic features according to the recent guidelines; (2) to determine if immunohistochemistry can be useful to identify extravillous trophoblast (EVT) and to measure the depth of infiltration into the myometrium to improve the diagnosis of PAS.

methodsThe retrospective study was conducted on 30 cases of gravid hysterectomy with histopathologic diagnosis of PAS. To identify the depth of EVT, immunohistochemical stainings were performed using anti MNF116 (cytokeratins 5, 6, 8, 17, 19), actin-SM, HPL (Human Placental Lactogen), vimentin and GATA3 antibodies.

resultsOur cases were graded based on the degree of invasion of the myometrium. Ten were grade 1 (33.3%), 12 grade 2 (40%) and 8 grade 3A (26.7%). EVT invasion was best seen and evident by double immunostainings with actin-SM and cytokeratins, actin-SM and HPL, actin-SM and GATA3.

conclusionThe role of pathologist is decisive to determine the different grades of PAS. A better understanding of the depth of myometrial invasion can be achieved by the use of immunohistochemistry affording an important tool to obtain reproducible grading of PAS. This purpose is crucial in the setting of postoperative quality reviews and particularly in the forensic medicine field.

Indexed as

ImmunohistochemistryPlacenta AccretaTrophoblastsActinsAdultFemaleGATA3 Transcription FactorHumansHysterectomyKeratinsMyometriumPlacental LactogenPregnancyRetrospective StudiesVimentinActinsGATA3 protein, humanGATA3 Transcription FactorKeratinsPlacental LactogenVimentinExtravillous trophoblastImmunohistochemistryPlacenta accreta spectrumPlacenta cretaPlacenta incretaPlacenta percreta

Identifiers

PMID37535133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.