Evidence map›Paper›PMID 37534741›Full record

ArticleHealth services research2023

Natural language processing to identify social determinants of health in Alzheimer's disease and related dementia from electronic health records.

Wenbo Wu, Kaes J Holkeboer, Temidun O Kolawole, Lorrie Carbone, Elham Mahmoudi

Abstract read
In one paragraph

Article in Health services research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Development of a natural language processing algorithm to extract social determinants of health from clinician notes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
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  15. Leveraging Social Determinants of Health in Alzheimer's Research Using LLM-Augmented Literature Mining and Knowledge Graphs.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025
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  17. On the development and validation of large language model-based classifiers for identifying social determinants of health.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenbo WuDepartments of Population Health and Medicine, Grossman School of Medicine, New York University, New York City, New York, USA.ORCID 0000-0002-7642-9773
Kaes J HolkeboerDepartment of Family Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Temidun O KolawoleKrieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Lorrie CarboneDepartment of Family Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Elham MahmoudiDepartment of Family Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-9746-8165

Funding

Pilot CoreP30AG066582 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie PW Bynum · 2020 to 2026
$7.2M
Using Machine Learning to Improve Readmission Prediction in Alzheimer's Disease and Related DementiaK01AG068361 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MAHMOUDI, ELHAM · 2020 to 2024
$651k
NIA NIH HHS K01 AG068361NIA NIH HHS P30 AG066582
6 · The paper itself

Abstract

objectiveTo develop a natural language processing (NLP) algorithm that identifies social determinants of health (SDoH), including housing, transportation, food, and medication insecurities, social isolation, abuse, neglect, or exploitation, and financial difficulties for patients with Alzheimer's disease and related dementias (ADRD) from unstructured electronic health records (EHRs). DATA SOURCES AND STUDY

settingWe leveraged 1000 medical notes randomly selected from 7401 emergency department and inpatient social worker notes generated between 2015 and 2019 for 231 unique patients diagnosed with ADRD at Michigan Medicine. STUDY

designWe developed a rule-based NLP algorithm for the identification of seven domains of SDoH noted above. We also compared the rule-based algorithm with deep learning and regularized logistic regression approaches. These models were compared using accuracy, sensitivity, specificity, F1 score, and the area under the receiver operating characteristic curve (AUC). All notes were split into 700 notes for training NLP algorithms, and 300 notes for validation. DATA COLLECTION/EXTRACTION

methodsSocial worker notes used in this study were extracted from the Michigan Medicine EHR database. PRINCIPAL

findingsOf the 700 notes for training, F1 and AUC for the rule-based algorithm were at least 0.94 and 0.95, respectively, for all SDoH categories. Of the 300 notes for validation, F1 and AUC were at least 0.80 and 0.97, respectively, for all SDoH except housing and medication insecurities. The deep learning and regularized logistic regression algorithms had unsatisfactory performance.

conclusionsThe rule-based algorithm can accurately extract SDoH information in all seven domains of SDoH except housing and medication insecurities. Findings from the algorithm can be used by clinicians and social workers to proactively address social needs of patients with ADRD and other vulnerable patient populations.

Indexed as

Alzheimer DiseaseElectronic Health RecordsAlgorithmsHumansNatural Language ProcessingSocial Determinants of HealthAlzheimer's disease and related dementiaelectronic health recordsmachine learningnatural language processingsocial determinants of health

Identifiers

PMID37534741
PMCPMC10622277

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.