Evidence map›Paper›PMID 37534634›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2023

[Expression and significance of INSM1 and SOX11 in pancreatic neuroendocrine tumor and solid pseudopapillary neoplasm].

Z Cao, H B Cen, J H Zhao, J Mei, L Z Qin, W Liao, Q L Ao

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Z CaoDepartment of Pathology, Huanggang Central Hospital, Huanggang 438000, Hubei, China.
H B CenDepartment of Pathology, Huanggang Central Hospital, Huanggang 438000, Hubei, China.
J H ZhaoDepartment of Pathology, Huanggang Central Hospital, Huanggang 438000, Hubei, China.
J MeiDepartment of Thyroid and Breast Surgery, Huanggang Central Hospital, Huanggang 438000, Hubei, China.
L Z QinInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
W LiaoDepartment of Respiratory and Critical Care Medicine, Fifth Hospital in Wuhan, 430050, China.
Q L AoInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression and significance of insulinoma associated protein 1 (INSM1) and SRY-related high-mobility group box 11 (SOX11) in pancreatic neuroendocrine tumor (PNET) and solid pseudopapillary neoplasm (SPN).

methodsTo detect the expression of INSM1, SOX11, Syn, CgA, CD56, β-catenin, and CD99 in 56 cases of PNET, 42 cases of SPN, 16 cases of ductal adenocarcinoma (DACC) and 8 cases of acinar cell carcinoma (ACC) by immunohistochemistry. The application value of combination of INSM1 and SOX11 was compared with conventional markers (Syn, CgA, CD56, β-catenin, and CD99) in diagnosis and differential diagnosis of PNET and SPN.

results(1) In the 56 cases of PNET, the positive signals of INSM1 were located in the tumor and islet nucleus, the positive expression rate in the tumor tissues was 91.07% (51/56), whereas the signal was absent in 42 cases of SPN, 16 cases of DACC and 8 cases of ACC, and there were significant statistical difference between PNET with SPN, DACC, and ACC respectively (

conclusionThe positive expression patterns of INSM1 and SOX11 in PNET and SPN respectively are conductive to distinguish the both tumors. The combination of both take precedence over some corresponding conventional immunohistochemical markers in terms of sensitivity and specificity.

Indexed as

Neuroectodermal Tumors, PrimitiveNeuroendocrine TumorsPancreatic Neoplasmsbeta CateninBiomarkers, TumorHumansRepressor ProteinsSOXC Transcription Factorsbeta CateninBiomarkers, TumorINSM1 protein, humanRepressor ProteinsSOX11 protein, humanSOXC Transcription FactorsBiomarkers, tumorInsulinoma associated protein 1Neuroendocrine tumorsPancreatic neoplasmsSRY-related high-mobility group box 11

Identifiers

PMID37534634
PMCPMC10398779
OpenAlexW4385513992

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.