Trial reportBrain and behavior2023
Short-term effects of SAFE early intervention approach in infants born preterm: A randomized controlled single-blinded study.
Trial report in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- Effects of SAFE Early Intervention Approach in the First Months of Life in Infants at Risk: A Randomized Controlled Study.Child: care, health and development · 2025Trial
- Early developmental support for preterm infants based on exploratory behaviors: A parallel randomized controlled study.Brain and behavior · 2023Trial
- Short-term effects of SAFE early intervention approach in infants born preterm: A randomized controlled single-blinded study.Brain and behavior · 2023Trial
- Life after the NICU: targeting modifiable factors to improve neurodevelopmental outcomes in children born extremely preterm.Pediatric research · 2026Review
- Mapping the landscape of early childhood development services: a global scoping review.BMJ open · 2026Article
- Effects of Safe Early Intervention Approach: A 3-Year Follow-Up.Brain and behavior · 2026Article
- Telehealth Delivery of the Homeostasis-Enrichment-Plasticity Approach for Premature Infants With Developmental Risks: Exploratory Feasibility Study.Journal of medical Internet research · 2026Article
- Effects of Task-Oriented Circuit Training on Dizziness, Vertigo Balance, Gait, and Quality of Life in Patients with Peripheral Vestibular Hypofunction: A Single-Blind, Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- Association between the motor optimality score-revised and clinical variables of preterm infants.BMC pediatrics · 2025Article
- Early Intervention Including an Active Motor Component in Preterms with Varying Risks for Neuromotor Delay: A Systematic Review and Narrative Synthesis.Journal of clinical medicine · 2025Review
- Effects of the HEP® (Homeostasis-Enrichment-Plasticity) Approach in preterm infants with increased developmental risk: a randomized controlled study.Frontiers in pediatrics · 2025Article
- An Integrated Review of Transitional Care for Families of Pre-Term Infants.Healthcare (Basel, Switzerland) · 2024Review
- The Homeostasis-Enrichment-Plasticity (HEPJournal of clinical medicine · 2024Article
- Relationship between sensory processing skills and motor skills in 12-month-old infants.Brain and behavior · 2024Article
- HEPChildren (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent literature suggests that goal-oriented and family-based interventions in enriched environment have a beneficial effect on neuromotor and cognitive development. We aimed to examine the short-term effects of SAFE (Sensory strategies, Activity-based motor training, Family collaboration, and Environmental Enrichment) early intervention approach on motor, cognitive, speech and language, and sensory development in preterm infants.
methodsThe study's sample population consisted of 24 preterm infants with corrected ages between 9 and 10 months. Infants in the control group participated in the family training program in accordance with the neurodevelopmental therapy principles (NDT). Infants in the treatment group were included in the family training program according to the principles of the SAFE Early Intervention Approach. Affordances in the Home Environment for Motor Development-Infant Scale (AHEMD-IS), Test of Sensory Functions in Infants (TSFI), Canadian Occupational Performance Measure (COPM), and Bayley Scales of Infant and Toddler Development III (Bayley III) were used to evaluate infants in both groups before and after 10 weeks of treatment (AHEMD-IS). The Depression, Anxiety, Stress Scale Short Form was used to assess the parents' mental health (DASS-SF).
resultsThe interaction effects (time × group) revealed significant differences for Bayley-III cognitive and language scores, TSFI total score, and AHEMD-IS total score in favor of the SAFE group (p < .05). However, there were no differences in Bayley-III motor composite score, COPM Performance score, and COPM Satisfaction score between the interaction effects (time × group) of the groups (p > .05).
conclusionsSAFE early intervention approach improved cognitive, speech and language, sensory outcomes and provide enriched home environment in all domains when compared to NDT-based home program. SAFE is a promising novel early intervention approach for preterm infants.
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