Evidence map›Paper›PMID 37534607›Full record

ArticleTransfusion2023

Transfusion reactions associated with COVID-19 convalescent plasma in outpatient clinical trials.

Moises A Huaman, Jay S Raval, James H Paxton, Giselle S Mosnaim, Bela Patel, Shweta Anjan, Barry R Meisenberg, Adam C Levine, Christi E Marshall, Anusha Yarava and 48 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

58 authors at 20 institutions in 1 country.

Moises A HuamanDepartment of Internal Medicine, Division of Infectious Diseases, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-6839-5809
Jay S RavalDepartment of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
James H PaxtonDepartment of Emergency Medicine, Wayne State University, Detroit, Michigan, USA.
Giselle S MosnaimDepartment of Medicine, Division of Allergy and Immunology, NorthShore University Health System, Evanston, Illinois, USA.
Bela PatelDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center, Houston, Texas, USA.
Shweta AnjanDepartment of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
Barry R MeisenbergLuminis Health, Annapolis, Maryland, USA.
Adam C LevineDepartment of Emergency Medicine, Rhode Island Hospital & Brown University, Providence, Rhode Island, USA.
Christi E MarshallDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Anusha YaravaDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Aarthi G ShenoyDepartment of Medicine, Division of Hematology and Oncology, MedStar Washington Hospital Center, DC, USA.
Sonya L HeathDepartment of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Judith S CurrierDepartment of Medicine, Division of Infectious Diseases, University of California, Los Angeles, USA.
Yuriko FukutaDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Janis E BlairDepartment of Medicine, Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Emily S SpivakDepartment of Medicine, Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Joann R PetriniNuvance Health, Danbury, Connecticut, USA.
Patrick B BroderickNuvance Health Danbury Hospital, Danbury, Connecticut, USA.
William RauschNuvance Health, Danbury, Connecticut, USA.
MarieElena CordiscoNuvance Health, Danbury, Connecticut, USA.
Jean HammelNuvance Health Norwalk Hospital, Norwalk, Connecticut, USA.
Benjamin GreenblattNuvance Health Norwalk Hospital, Norwalk, Connecticut, USA.
Valerie C CluzetNuvance Health Vassar Brothers Medical Center, Poughkeepsie, New York, USA.
Daniel CruserNuvance Health Vassar Brothers Medical Center, Poughkeepsie, New York, USA.
Kevin OeiAscada Research, Fullerton, California, USA.
Matthew AbinanteAscada Research, Fullerton, California, USA.
Laura L HammittDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Catherine G SutcliffeDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Donald N ForthalDepartment of Medicine, Division of Infectious Diseases, University of California, Irvine, California, USA.
Martin S ZandDepartment of Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Edward R CachayDepartment of Medicine, Division of Infectious Diseases, University of California, San Diego, California, USA.
Seble G KassayeDepartment of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, DC, USA.
Malathi RamDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Ying WangDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Piyali DasDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Karen LaneDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nichol A McBeeDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Amy L GawadDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nicky KarlenDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Daniel E FordInstitute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Oliver LaeyendeckerThe Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Andrew PekoszDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Sabra L KleinDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Stephan EhrhardtDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Bryan LauDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Sheriza N BakshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
David M ShadeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Daniel F HanleyDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jiangda OuDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Thomas J GniadekDepartment of Pathology and Laboratory Medicine, NorthShore University Health System, Evanston, Illinois, USA.
Alyssa ZimanDepartment of Pathology and Laboratory Medicine, Wing-Kwai and Alice Lee-Tsing Chung Transfusion Service, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0002-1814-9319
Shmuel ShohamDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kelly A GeboDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Evan M BlochDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8181-9517
Aaron A R TobianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0517-3766
David J SullivanDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-0319-0578
Jonathan M GerberDepartment of Medicine, Division of Hematology and Oncology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Johns Hopkins University · USWestern Connecticut Health Network · USFullerton College · USNorthShore University HealthSystem · USNorwalk Hospital · USUniversity of California, Los Angeles · USVassar Brothers Medical Center · USAnne Arundel Medical Center · USBaylor College of Medicine · USBrown University · USDanbury Hospital · USGeorgetown University · USMayo Clinic Hospital · USMedStar Washington Hospital Center · USNational Institute of Allergy and Infectious Diseases · USThe University of Texas Health Science Center at Houston · USUniversity of Alabama at Birmingham · USUniversity of California, Irvine · USUniversity of California System · USUniversity of Cincinnati · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Johns Hopkins-Tufts Trial Innovation Center HEAL Pain ERN SupplementU24TR001609 · NCATS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2016 to 2022
$36.3M
CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
Colliding Epidemics During an Opioid Crisis: Impact of the COVID-19 Pandemic on Determinants of HIV and HCV Transmission Among People Who Inject DrugsF31DA054849 · NIDA · JOHNS HOPKINS UNIVERSITY · PI PATEL, ESHAN UDAY · 2021 to 2023
$140k
NCATS NIH HHS U24 TR001609NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR003098NCATS NIH HHS UM1 TR004409NIAID NIH HHS R01 AI120938NIAID NIH HHS R01 AI152078NIDA NIH HHS F31 DA054849
6 · The paper itself

Abstract

backgroundCOVID-19 convalescent plasma (CCP) is an important therapeutic option for outpatients at high risk of hospitalization from SARS-CoV-2 infection. We assessed the safety of outpatient CCP transfusions administered during clinical trials. STUDY DESIGN AND

methodsWe analyzed data pertaining to transfusion-related reactions from two randomized controlled trials in the U.S. that evaluated the efficacy of CCP versus control plasma in various ambulatory settings. Multivariable logistic regression was used to assess whether CCP was associated with transfusion reactions, after adjusting for potential confounders.

resultsThe combined study reported 79/1351 (5.9%) adverse events during the transfusion visit, with the majority 62/1351 (4.6%) characterized by mild, allergic-type findings of urticaria, and/or pruritus consistent with minor allergic transfusion reactions; the other reported events were attributed to the patients' underlying disease, COVID-19, or vasovagal in nature. We found no difference in the likelihood of allergic transfusion reactions between those receiving CCP versus control plasma (adjusted odds ratio [AOR], 0.75; 95% CI, 0.43-1.31). Risk of urticaria and/or pruritus increased with a pre-existing diagnosis of asthma (AOR, 2.33; 95% CI, 1.16-4.67). We did not observe any CCP-attributed antibody disease enhancement in participants with COVID-19 or increased risk of infection. There were no life-threatening severe transfusion reactions and no patients required hospitalization related to transfusion-associated complications. DISCUSSION: Outpatient plasma administration was safely performed for nearly 1400 participants. CCP is a safe therapeutic option for outpatients at risk of hospitalization from COVID-19.

Indexed as

COVID-19Transfusion ReactionUrticariaCOVID-19 SerotherapyHumansImmunization, PassiveOutpatientsRandomized Controlled Trials as TopicSARS-CoV-2

Identifiers

PMID37534607
PMCPMC10720768
OpenAlexW4385514459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.