Evidence map›Paper›PMID 37534447›Full record

ArticleHuman vaccines & immunotherapeutics2023

Risk reduction analysis of mix-and-match vaccination strategy in healthcare workers during SARS-CoV-2 Omicron variant predominant period: A multi-center cohort study in Taiwan.

Yi-Ching Chen, Chih-Hsien Chuang, Tsai-Fong Shen, Chun-Sui Lin, Hsin-Ping Yang, Hsin-Chieh Li, Chyi-Liang Chen, I-Feng Lin, Cheng-Hsun Chiu

Abstract readMulticenter Study
In one paragraph

Article in Human vaccines & immunotherapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi-Ching ChenDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Chih-Hsien ChuangMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Tsai-Fong ShenOccupational Safety and Health Department, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chun-Sui LinInfection Control Committee, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Hsin-Ping YangMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Hsin-Chieh LiMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chyi-Liang ChenMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
I-Feng LinInstitute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Cheng-Hsun ChiuDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.ORCID 0000-0003-4324-7743

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the relative effectiveness of a mix-and-match vaccination strategy, primarily comprising ChAdOx1 nCOV-19, mRNA-1273, BNT162b2, and a protein-based vaccine, MVC-COV1901, against COVID-19 in a healthcare worker (HCW) cohort in Taiwan during a period when the Omicron variant was predominant. The analysis included a total of 21,729 HCWs and recorded 3,672 infections with no severe disease nor death. Two main findings were observed from the study. Firstly, for those with ChAdOx1 nCOV-19 as primary series, a booster dose with BNT162b2 was associated with a small decrease in the risk of acquiring infection compared to those with mRNA-1273 as a booster (Adjust hazard ratio [Adj HR] 0.864; 95% confidence interval [CI] 0.761‒0.981,

Indexed as

COVID-19SARS-CoV-22019-nCoV Vaccine mRNA-1273BNT162 VaccineChAdOx1 nCoV-19Health PersonnelHumansProspective StudiesRisk Reduction BehaviorTaiwanVaccination2019-nCoV Vaccine mRNA-1273BNT162 VaccineChAdOx1 nCoV-19boosterCOVID-19healthcare workerprimary seriesvaccination

Identifiers

PMID37534447
PMCPMC10402828

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.