Evidence map›Paper›PMID 37534335›Full record

ArticleFrontiers in integrative neuroscience2023

Contextualizing the impact of prenatal alcohol and tobacco exposure on neurodevelopment in a South African birth cohort: an analysis from the socioecological perspective.

Yingjing Xia, Vida Rebello, Stefanie C Bodison, Deborah Jonker, Babette Steigelmann, Kirsten A Donald, Weslin Charles, Dan J Stein, Jonathan Ipser, Hedyeh Ahmadi and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in integrative neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Yingjing XiaPublic Health, University of California, Irvine, Irvine, CA, United States.
Vida RebelloPublic Health, University of California, Irvine, Irvine, CA, United States.
Stefanie C BodisonDepartment of Occupational Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States.
Deborah JonkerDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Babette SteigelmannPublic Health, University of California, Irvine, Irvine, CA, United States.
Kirsten A DonaldDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Weslin CharlesDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Jonathan IpserNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Hedyeh AhmadiUniversity Statistical Consulting, LLC, Irvine, CA, United States.
Eric KanDepartment of Pediatrics, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States.
Elizabeth R SowellDepartment of Pediatrics, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States.
Katherine L NarrDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States.
Shantanu H JoshiAhmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Hein J OdendaalDepartment of Obstetrics and Gynaecology, Stellenbosch University, Cape Town, South Africa.
Kristina A UbanPublic Health, University of California, Irvine, Irvine, CA, United States.
University of Cape Town · ZAUniversity of California, Irvine · USUniversity of Southern California · USBrain Mapping Foundation · USStellenbosch University · ZAUniversity of California, Los Angeles · USUniversity of Florida · US

Funding

Brain and Cognitive Development in the PASS Cohort: The Impact of PrenatalAlcohol ExposureR01AA025653 · NIAAA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI ELIZABETH R SOWELL · 2017 to 2026
$5.4M
Assessing Stable Characteristics of Endocrine Function Among Boys and Girls with Prenatal Alcohol Exposure as a Novel Clinical ToolK01AA026889 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI UBAN, KRISTINA ANDREA · 2018 to 2022
$894k
NIAAA NIH HHS K01 AA026889NIAAA NIH HHS R01 AA025653
6 · The paper itself

Abstract

Background: Alcohol and tobacco are known teratogens. Historically, more severe prenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) have been examined as the principal predictor of neurodevelopmental alterations, with little incorporation of lower doses or ecological contextual factors that can also impact neurodevelopment, such as socioeconomic resources (SER) or adverse childhood experiences (ACEs). Here, a novel analytical approach informed by a socio-ecological perspective was used to examine the associations between SER, PAE and/or PTE, and ACEs, and their effects on neurodevelopment. Methods: Results: Greater access to SER during pregnancy was associated with fewer ACEs (maternal education: β = -0.293, Conclusion: Research on neurodevelopment following community-levels of PAE and PTE should more regularly consider the ecological context to accelerate understanding of teratogenic outcomes. Further research is needed to replicate this novel conceptual approach with varying PAE and PTE patterns, to disentangle the interplay between dose, community-level and individual-level risk factors on neurodevelopment.

Indexed as

adverse childhood experiencesneurodevelopmentprenatal alcohol exposureprenatal substance exposureprenatal tobacco exposuresocioeconomic resources

Identifiers

PMID37534335
PMCPMC10390790
OpenAlexW4384693113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.