Evidence map›Paper›PMID 37534237›Full record

ArticleRegenerative therapy2023

Promotion of skin wound healing using hypoimmunogenic epidermal cell sheets.

Hongqing Zhao, Jiachen Sun, Yating Wu, Junbo Zhang, Chuan'an Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Hongqing ZhaoNanbu County People's Hospital, Nanchong City, Sichuan Province, 637300, China.
Jiachen SunJinzhou Medical University, No.82 Songpo Road, Guta District, Jinzhou 121001, Liaoning Province, China.
Yating WuJinzhou Medical University, No.82 Songpo Road, Guta District, Jinzhou 121001, Liaoning Province, China.
Junbo ZhangJinzhou Medical University, No.82 Songpo Road, Guta District, Jinzhou 121001, Liaoning Province, China.
Chuan'an ShenDepartment of Burn Surgery, Fourth Medical Center, PLA General Hospital, No 51 Fucheng Road, Haidian District, Beijing 100089, China.
Jinzhou Medical University · CNChinese PLA General Hospital · CNNanchong Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The physiological process of wound healing is dynamic, continuous, and intricate. Nowadays, full-thickness burn wounds are treated by autologous skin transplantation. Unfortunately, when substantial burns develop, there are fewer donor sites accessible, making it difficult to satisfy the requirement for large-scale skin transplants and increasing the risk of patient mortality. This study investigated the possibility of using a newly created hypoimmunogenic epidermal cell sheet to heal skin wounds. Methods: Transfection with lentivirus was used to generate Keratinocytes (KCs) that overexpress Indoleamine 2,3-Dioxygenase (IDO). Western blotting and quantitative polymerase chain reaction were used to measure IDO levels. To evaluate the function of IDO Results: IDO Conclusion: In this study, we successfully constructed the hypoimmunogenic epidermal cell sheet and demonstrated that the hypoimmunogenic epidermal cell sheet could accelerate wound healing.

Indexed as

Allogenic skin substituteEpidermal cell sheetIndoleamine 2,3-dioxygenaseSkinWound healing

Identifiers

PMID37534237
PMCPMC10393516
OpenAlexW4385404875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.