Evidence map›Paper›PMID 37534218›Full record

ArticleJournal of oral microbiology2023

Defining

Wenya Xue, Manon F Pritchard, Saira Khan, Lydia C Powell, Joana Stokniene, Jingxiang Wu, Nicholas Claydon, Paul Reddell, David W Thomas, Katja E Hill

Open access · goldAbstract read
In one paragraph

Article in Journal of oral microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wenya XueAdvanced Therapies Group, Cardiff School of Dentistry, Heath Park, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-6842-1288
Manon F PritchardAdvanced Therapies Group, Cardiff School of Dentistry, Heath Park, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-5135-4744
Saira KhanAdvanced Therapies Group, Cardiff School of Dentistry, Heath Park, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-3284-3198
Lydia C PowellMicrobiology and Infectious Disease Group, Swansea University Medical School, Swansea, UK.ORCID https://orcid.org/0000-0002-8641-0160
Joana StoknieneAdvanced Therapies Group, Cardiff School of Dentistry, Heath Park, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-8836-4209
Jingxiang WuAdvanced Therapies Group, Cardiff School of Dentistry, Heath Park, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0009-0008-8907-7368
Nicholas ClaydonAdvanced Therapies Group, Cardiff School of Dentistry, Heath Park, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-4151-1515
Paul ReddellQBiotics Group Limited, Yungaburra, Queensland, Australia.ORCID https://orcid.org/0000-0002-0993-8957
David W ThomasAdvanced Therapies Group, Cardiff School of Dentistry, Heath Park, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0001-7319-5820
Katja E HillAdvanced Therapies Group, Cardiff School of Dentistry, Heath Park, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-8590-0117
Cardiff University · GBSwansea University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Peri-implantitis has become an inexorable clinical challenge in implantology. Topical immunomodulatory epoxy-tiglianes (EBCs), derived from the Queensland blushwood tree, which induce remodeling and resolve dermal infection via induction of the inflammasome and biofilm disruption, may offer a novel therapeutic approach. Design: Results: The observed antimicrobial efficacy of the tested compounds (EBC-1013 > EBC-46 > EBC-147) was directly related to significant membrane permeabilization and growth inhibition ( Conclusions: EBC-1013 is a safe, semi-synthetic, compound, demonstrating clear antimicrobial biofilm disruption potential in peri-implantitis.

Indexed as

antimicrobial therapybiofilmDental implantsepoxy-tiglianesperi-implantitistitanium

Identifiers

PMID37534218
PMCPMC10392292
OpenAlexW4385410526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.