Evidence map›Paper›PMID 37534178›Full record

ArticleiScience2023

Excitatory amino acid transporter 1 supports adult hippocampal neural stem cell self-renewal.

Joshua D Rieskamp, Ileanexis Rosado-Burgos, Jacob E Christofi, Eliza Ansar, Dalia Einstein, Ashley E Walters, Valentina Valentini, John P Bruno, Elizabeth D Kirby

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Joshua D RieskampDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Ileanexis Rosado-BurgosDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Jacob E ChristofiDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Eliza AnsarDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Dalia EinsteinDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Ashley E WaltersDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Valentina ValentiniDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
John P BrunoDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Elizabeth D KirbyDepartment of Psychology, The Ohio State University, Columbus, OH 43210, USA.
The Ohio State University · USUniversity of Cagliari · IT

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Regulation of Adult Hippocampal Neural Stem Cells by Glutamate TransportR21NS123797 · NINDS · OHIO STATE UNIVERSITY · PI KIRBY, ELIZABETH DIANA · 2021 to 2022
$489k
NCI NIH HHS P30 CA016058NINDS NIH HHS R21 NS123797
6 · The paper itself

Abstract

Within the adult mammalian dentate gyrus (DG) of the hippocampus, glutamate stimulates neural stem cell (NSC) self-renewing proliferation, providing a link between adult neurogenesis and local circuit activity. Here, we show that glutamate-induced self-renewal of adult DG NSCs requires glutamate transport via excitatory amino acid transporter 1 (EAAT1) to stimulate lipogenesis. Loss of EAAT1 prevented glutamate-induced self-renewing proliferation of NSCs

Indexed as

BiochemistryCell biologyMolecular biologyNeurology

Identifiers

PMID37534178
PMCPMC10391730
OpenAlexW4379877889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.