ArticleiScience2023
How and when EEG reflects changes in neuronal connectivity due to time awake.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Human data at odds and in confirmation of the two-process model of sleep regulation-a perspective.Npj biological timing and sleep · 2026Review
- Article
- EEG Spectral Analysis of Tinnitus Sound Therapy: Meta-Analysis.Journal of otology · 2026Review
- Exploring the differences in neural oscillation mechanisms before and after sleep deprivation.Frontiers in neuroscience · 2026Article
- Wake EEG oscillation dynamics reflect both sleep pressure and brain maturation across childhood and adolescence.bioRxiv : the preprint server for biology · 2025Article
- Extended wakefulness alters the relationship between EEG oscillations and performance in a sustained attention task.Journal of sleep research · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Being awake means forming new memories, primarily by strengthening neuronal synapses. The increase in synaptic strength results in increasing neuronal synchronicity, which should result in higher amplitude electroencephalography (EEG) oscillations. This is observed for slow waves during sleep but has not been found for wake oscillations. We hypothesized that this was due to a limitation of spectral power analysis, which does not distinguish between changes in amplitudes from changes in number of occurrences of oscillations. By using cycle-by-cycle analysis instead, we found that theta and alpha oscillation amplitudes increase as much as 30% following 24 h of extended wake. These increases were interrupted during the wake maintenance zone (WMZ), a window just before bedtime when it is difficult to fall asleep. We found that pupil diameter increased during this window, suggesting the ascending arousal system is responsible. In conclusion, wake oscillation amplitudes reflect increased synaptic strength, except during the WMZ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.