Evidence map›Paper›PMID 37534138›Full record

ArticleiScience2023

Molecular components of the circadian clock regulate HIV-1 replication.

Helene Borrmann, Görkem Ulkar, Anna E Kliszczak, Dini Ismed, Mirjam Schilling, Andrea Magri, James M Harris, Peter Balfe, Sridhar Vasudevan, Persephone Borrow and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. BioClocks UK: driving robust cycles of discovery to impact.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Helene BorrmannNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Görkem UlkarNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Anna E KliszczakNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Dini IsmedNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Mirjam SchillingNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Andrea MagriNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
James M HarrisNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Peter BalfeNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Sridhar VasudevanDepartment of Pharmacology, University of Oxford, Oxford, UK.
Persephone BorrowNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Xiaodong ZhuangNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Jane A McKeatingNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

Funding

Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI164567 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2021 to 2026
$31.6M
NIAID NIH HHS UM1 AI164567
6 · The paper itself

Abstract

Human immunodeficiency virus 1 (HIV-1) causes major health burdens worldwide and still lacks curative therapies and vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism's response to its environment and invading pathogens. Peripheral viral loads of HIV-1 infected patients show diurnal variation; however, the underlying mechanisms remain unknown. Here, we demonstrate a role for the cell-intrinsic clock to regulate rhythmic HIV-1 replication in circadian-synchronized systems. Silencing the circadian activator

Indexed as

BioinformaticsBiological sciencesMolecular biologyVirology

Identifiers

PMID37534138
PMCPMC10391662

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.