Evidence map›Paper›PMID 37534130›Full record

ArticleiScience2023

Isogenic human trophectoderm cells demonstrate the role of

Liuliu Yang, Yuling Han, Ting Zhou, Lauretta A Lacko, Mohsan Saeed, Christina Tan, Ron Danziger, Jiajun Zhu, Zeping Zhao, Clare Cahir and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 1 country.

Liuliu YangDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Yuling HanDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Ting ZhouDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Lauretta A LackoDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Mohsan SaeedLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Christina TanDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Ron DanzigerDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Jiajun ZhuDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Zeping ZhaoDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Clare CahirDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Alice Maria GianiDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Yang LiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Xue DongDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Dorota MoroziewiczThe New York Stem Cell Foundation Research Institute, 619 West 54th Street, 3Road Floor, New York, NY 10019, USA.
NYSCF Global Stem Cell Array® Team
Daniel PaullThe New York Stem Cell Foundation Research Institute, 619 West 54th Street, 3Road Floor, New York, NY 10019, USA.
Zhengming ChenDepartment of Population Health Sciences, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Aaron ZhongStem Cell Research Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Scott A NoggleThe New York Stem Cell Foundation Research Institute, 619 West 54th Street, 3Road Floor, New York, NY 10019, USA.
Charles M RiceLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Qibin QiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Todd EvansDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Shuibing ChenDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Cornell University · USNew York Stem Cell Foundation · USAlbert Einstein College of Medicine · USMemorial Sloan Kettering Cancer Center · USBoston University · USRockefeller University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Unraveling yellow fever 17D vaccine attenuation: The role of type I interferon and innate immunityR01AI124690 · NIAID · ROCKEFELLER UNIVERSITY · PI Charles M Rice · 2016 to 2026
$8.3M
Type I interferon-stimulated genes and the antiviral immune responseR01AI091707 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2011 to 2020
$5.5M
Determining the Intrinsic and Environmental Signal Contributing to Early T1D ProgressionU01DK127777 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING, PARKER, STEPHEN CJ · 2020 to 2023
$3.0M
Metallothionein 1E as a Central Regulator of Human Pancreatic Beta Cell Function and SurvivalR01DK119667 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2019 to 2022
$2.5M
A High Content Chemical Screen to Identify the Drug Candidates Promoting Human Beta Cell ProliferationR01DK124463 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2020 to 2023
$1.7M
Decode the Impact of SARS-CoV-2 on Human PancreasR01DK130454 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING, LIM, JEAN KYOU · 2021 to 2023
$1.3M
Effect of Pre- and Peri-Implantation Zika Virus Infection on Fetal DevelopmentF32HD096810 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI LACKO, LAURETTA A. · 2019 to 2021
$212k
NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI091707NIAID NIH HHS R01 AI124690NICHD NIH HHS F32 HD096810NIDDK NIH HHS R01 DK119667NIDDK NIH HHS R01 DK124463NIDDK NIH HHS R01 DK130454NIDDK NIH HHS U01 DK127777
6 · The paper itself

Abstract

Population-based genome-wide association studies (GWAS) normally require a large sample size, which can be labor intensive and costly. Recently, we reported a human induced pluripotent stem cell (hiPSC) array-based GWAS method, identifying NDUFA4 as a host factor for Zika virus (ZIKV) infection. In this study, we extended our analysis to trophectoderm cells, which constitute one of the major routes of mother-to-fetus transmission of ZIKV during pregnancy. We differentiated hiPSCs from various donors into trophectoderm cells. We then infected cells carrying loss of function mutations in

Indexed as

Stem cells researchVirology

Identifiers

PMID37534130
PMCPMC10391681
OpenAlexW4378713759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.