Evidence map›Paper›PMID 37534069›Full record

ReviewJournal of advanced veterinary and animal research2023

Autophagy characteristics of phytoestrogens in management and prevention of diseases: A narrative review of

Safaa I Khater, Maram Shalabi, Buthainah B Alammash, Alaa I Alrais, Doaa Al-Ahmadi, Leena S Alqahtani, Tarek Khamis, Sahar Abdelaziz, Khalifa Aldawy

Open access · goldAbstract readReview
In one paragraph

Review in Journal of advanced veterinary and animal research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Safaa I KhaterDepartment of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Maram ShalabiDepartment of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Buthainah B AlammashKing Fahad Hospital, Ministry of Health, Medina, Saudi Arabia.
Alaa I AlraisKing Fahad Hospital, Ministry of Health, Medina, Saudi Arabia.
Doaa Al-AhmadiMaternity and Children Hospital (MCH), Ministry of Health, Medina, Saudi Arabia.
Leena S AlqahtaniDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah 23445, Saudi Arabia.
Tarek KhamisDepartment of Pharmacology, Laboratory of Biotechnology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Sahar AbdelazizDepartment of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Khalifa AldawyDepartment of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University · EGJeddah University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytoestrogens are non-steroid polyphenolic materials present in 300 plants. Regarding their structural similarities to estradiol, phytoestrogens attach to estrogen receptors and display anti- or pro-estrogenic activities. This review explored phytoestrogens' potential advantages and autophagy properties in light of their future application for disease management, highlighting how phytoestrogens could modulate autophagy. Research has examined the prospective benefits of phytoestrogens for the anticipation and management of various conditions, including signs of menopause, tumors, skin deterioration, osteoporosis, heart disease, neurodegenerative conditions, disorders of the immune system, and metabolic syndrome, owing to their therapeutic effects. As phytoestrogens can activate or inhibit autophagy, which has antioxidant, apoptotic, anti-mutagenic, anticancer, transcriptional, and genomic impacts on cancer and aging illnesses, phytoestrogens could influence diseases through the modulation of autophagy. The collaborative research on animal models, utilization of genetic techniques, and administration of pharmacologically active substances has indicated the possible therapeutic benefits of autophagy modulation in various illnesses. Further research is required to illustrate the pathways by which phytoestrogens modulate autophagy and the possible therapeutic effects on these diseases.

Indexed as

AMP-activated protein kinase (AMPK)autophagycancercoumestansisoflavoneslignansphytoestrogensstilbenes

Identifiers

PMID37534069
PMCPMC10390686
OpenAlexW4385151230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.