Evidence map›Paper›PMID 37533779›Full record

ArticleRSC advances2023

Design of screen-printed potentiometric platform for sensitive determination of mirabegron in spiked human plasma; molecular docking and transducer optimization.

Aya A Mouhamed, Basma M Eltanany, Nadia M Mostafa, Tamer A Elwaie, Ahmed H Nadim

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Aya A MouhamedDepartment of Analytical Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini St. Cairo 11562 Egypt ahmed.nagib@pharma.cu.edu.eg.ORCID https://orcid.org/0000-0001-8213-3664
Basma M EltananyDepartment of Analytical Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini St. Cairo 11562 Egypt ahmed.nagib@pharma.cu.edu.eg.
Nadia M MostafaDepartment of Analytical Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini St. Cairo 11562 Egypt ahmed.nagib@pharma.cu.edu.eg.
Tamer A ElwaieDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini St. Cairo 11562 Egypt.
Ahmed H NadimDepartment of Analytical Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini St. Cairo 11562 Egypt ahmed.nagib@pharma.cu.edu.eg.
Cairo University · EGTexas A&M Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of molecular modelling simulation and electrochemical sensors is of high interest. Herein, for the first time, a portable solid-contact potentiometric electrode was designed for the sensitive determination of mirabegron (MIR) in human plasma and pharmaceutical formulation. A two-step optimization protocol was investigated for the fabrication of an ion on sensing polymeric membrane. First, molecular docking was used for optimum ionophore selection. Calix[6]arene showed the highest affinity towards MIR with a better docking score (-4.35) and potential energy (-65.23) compared to other calixarene derivatives. Second, carbon nanotubes and gold nanoparticles were investigated as ion-electron transducers using a drop-casting procedure. Gold nanoparticle-based sensors showed better slope, potential stability, and rapid response compared to carbon nanotubes. The proposed solid contact sensors (V-VII) showed comparable sensitivity and ease of handling compared to liquid contact sensors (I-IV). The optimized gold nanoparticles sensor VII produced a Nernstian response over the range of 9.77 × 10

Identifiers

PMID37533779
PMCPMC10391324
OpenAlexW4385447348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.