ReviewNature and science of sleep2023
The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain.
Review in Nature and science of sleep, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- The Effects of Digital Cognitive Behavioral Therapy for Insomnia in Chronic Pain: A Randomized Controlled Trial.Psychotherapy and psychosomatics · 2026Trial
- An explorative cross-sectional study on the association between immunological biomarkers in patients with chronic pain.Brain, behavior, & immunity - health · 2026Article
- The interconnection between obstructive sleep apnoea and spondyloarthritis: pathophysiology, clinical evidence, and future perspectives.Rheumatology international · 2026Review
- Review
- Association Between Sleep Quality and Postcolonoscopy Pain.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Observational
- Screening and Management of Sleep Disorders in Patients with Fibromyalgia Syndrome: A French Multicenter, Prospective, Observational Study.Pain and therapy · 2026Article
- Linking sleep apnea and arthritis in the National Alzheimer Coordinating Center Cohort: A cross-sectional analysis.Medicine · 2026Article
- Acupuncture for Comorbid Chronic Nonspecific Neck Pain and Chronic Insomnia: Protocol for a Multicenter, Randomized, Sham-Controlled Trial.Journal of pain research · 2026Article
- Sleep Disturbance, Treatment-Related Adverse Events, and Psychological Distress in Breast Cancer Patients: A Prospective Cohort Study.Patient preference and adherence · 2026Article
- Association of Baseline Systemic Immune-Inflammation Index With Severe Sleep Disturbance in Patients With Neuropathic Pain: A Prospective Longitudinal Observational Cohort Study.Pain research & management · 2026Observational
- Sleep quality and injury risk in adolescent football players: an amplified effect for high-risk athletes revealed by quantile regression.Frontiers in public health · 2026Article
- Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture.Acta pharmaceutica Sinica. B · 2025Article
- The clinical impact of chronopharmacology on current medicine.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Sleep disturbance and multimorbidity: a cross-sectional and longitudinal study in the knee pain and related health in the community cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Relationship Between Sleep Disturbances and Chronic Pain: A Narrative Review.Clinics and practice · 2024Review
- Narcolepsy: an interface among neurology, immunology, sleep, and genetics.Arquivos de neuro-psiquiatria · 2024Article
- The crucial role of locus coeruleus noradrenergic neurons in the interaction between acute sleep disturbance and headache.The journal of headache and pain · 2024Article
- Neuropathic Component Characteristics in Chronic Secondary Musculoskeletal Pain After Postmenopausal Osteoporotic Fractures: A Pilot Cross-Sectional Study.Pain research & management · 2024Article
- The contribution of clock genes BMAL1 and PER2 in osteoarthritis-associated pain.Neurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in animals and humans, for example by increasing sensitivity to pain. However, the mechanism by which sleep affects neuropathic pain remains unclear. In this review, we discuss the available evidence from the epidemiologic, clinical, and human, as well as laboratory studies. In previous studies, we have found that sleep deprivation affects various injurious systems, including opioids, dopaminergic, immune, orexins, hypothalamic-pituitary-adrenal axis, and adenosine. At the same time, these systems play a crucial role in neuropathic pain regulation. In the complex interactions between these neurobiological systems, there may be potential regulatory pathways through which sleep deprivation amplifies neuropathic pain. Because of the impact sleep problems and neuropathic pain can have on the patients' quality of life, studying the link between sleep and neuropathic pain is important for neuropathic pain prevention and public health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.