Trial reportFrontiers in public health2023
Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial.
Trial report in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04756557 (Caries-preventing Effect of a Hydroxyapatite-toothpaste in Adults), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Caries-preventing Effect of a Hydroxyapatite-toothpaste in Adults
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Cytotoxicity, antibacterial efficacy, and fluoride content of commercial herbal toothpastes.BDJ open · 2026Article
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- Evaluating the combined effect of a biomimetic organic matrix and bioinspired fluorapatite nanoparticles on initial caries lesions.RSC advances · 2026Article
- In vitro study on the neutralization potential of particulate hydroxyapatite in erosive acids.BDJ open · 2026Article
- Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study.Biomimetics (Basel, Switzerland) · 2026Article
- Fluoride-Free Toothpastes for Caries Prevention: A Systematic Review of Clinical Evidence on Active Ingredients.Clinical, cosmetic and investigational dentistry · 2026Review
- Oral Manifestations of Sjögren's Syndrome: Recognition, Management, and Interdisciplinary Care.Medicina (Kaunas, Lithuania) · 2025Review
- Article
- The Remineralizing and Desensitizing Potential of Hydroxyapatite in Dentistry: A Narrative Review of Recent Clinical Evidence.Journal of functional biomaterials · 2025Review
- Nano-Hydroxyapatite-Based Mouthwash for Comprehensive Oral Care: Activity Against Bacterial and Fungal Pathogens with Antioxidant and Anti-Inflammatory Action.Materials (Basel, Switzerland) · 2025Article
- How the public's knowledge, attitudes, and practice intersect with scientific evidence about fluoride.Current problems in pediatric and adolescent health care · 2025Article
- Evaluation of the Efficacy of a Dentifrice Tablet to Prevent Dental Caries: A Microbial Study.Dentistry journal · 2025Article
- The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries.Frontiers in cellular and infection microbiology · 2025Review
- Case Report on Caries Assessment Using Intraoral Scanner Compared with Bitewing Radiographs.European journal of dentistry · 2024Article
- Caries Etiology and Preventive Measures.European journal of dentistry · 2024Article
- Doses of fluoride toothpaste for children up to 24 months.BDJ open · 2024Article
- Review
- Review
- Improving Oral Health with Fluoride-Free Calcium-Phosphate-Based Biomimetic Toothpastes: An Update of the Clinical Evidence.Biomimetics (Basel, Switzerland) · 2023Review
- The composition of the dental pellicle: an updated literature review.Frontiers in oral health · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dental caries is a worldwide challenge for public health. The aim of this 18-month double-blinded, randomized, clinical trial was to compare the caries-preventing effect of a fluoride-free, hydroxyapatite toothpaste (test) and a toothpaste with sodium fluoride (1450 ppm fluoride; positive control) in adults. Methods: The primary endpoint was the percentage of subjects showing no increase in overall Decayed Missing Filled Surfaces (DMFS) index. The study was designed as non-inferiority trial. Non-inferiority was claimed if the upper limit of the exact one-sided 95% confidence interval for the difference of the primary endpoint DMFS between test and control toothpaste was less than the predefined margin of non-inferiority (Δ ≤ 20%). Results: In total, 189 adults were included in the intention-to-treat (ITT) analysis; 171 subjects finished the study per protocol (PP). According to the PP analysis, no increase in DMFS index was observed in 89.3% of subjects of the hydroxyapatite group and 87.4% of the subjects of the fluoride group. The hydroxyapatite toothpaste was not statistically inferior to a fluoride toothpaste with regard to the primary endpoint. Conclusion: Hydroxyapatite was proven to be a safe and efficient anticaries agent in oral care. Clinical trial registration: NCT04756557.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.