Evidence map›Paper›PMID 37533245›Full record

ArticleCurrent neuropharmacology2024

Sensory Reinforced Corticostriatal Plasticity.

Nicolas Vautrelle, Véronique Coizet, Mariana Leriche, Lionel Dahan, Jan M Schulz, Yan-Feng Zhang, Abdelhafid Zeghbib, Paul G Overton, Enrico Bracci, Peter Redgrave and 1 more

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Article in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicolas VautrelleDepartment of Anatomy, Brain Health Research Centre, University of Otago, Dunedin 9054, New Zealand.
Véronique CoizetDepartment of Psychology, University of Sheffield, Sheffield, S10 2TP, UK.
Mariana LericheDepartment of Anatomy, Brain Health Research Centre, University of Otago, Dunedin 9054, New Zealand.
Lionel DahanDepartment of Psychology, University of Sheffield, Sheffield, S10 2TP, UK.
Jan M SchulzDepartment of Anatomy, Brain Health Research Centre, University of Otago, Dunedin 9054, New Zealand.
Yan-Feng ZhangDepartment of Anatomy, Brain Health Research Centre, University of Otago, Dunedin 9054, New Zealand.
Abdelhafid ZeghbibDepartment of Psychology, University of Sheffield, Sheffield, S10 2TP, UK.
Paul G OvertonDepartment of Psychology, University of Sheffield, Sheffield, S10 2TP, UK.
Enrico BracciDepartment of Psychology, University of Sheffield, Sheffield, S10 2TP, UK.
Peter RedgraveDepartment of Psychology, University of Sheffield, Sheffield, S10 2TP, UK.
John N J ReynoldsDepartment of Anatomy, Brain Health Research Centre, University of Otago, Dunedin 9054, New Zealand.

Funding

Marsden Fund of the Royal Society of New Zealand UOO0513, UOO0904, UOO1802Wellcome TrustWellcome Trust 080943, 091409
6 · The paper itself

Abstract

backgroundRegional changes in corticostriatal transmission induced by phasic dopaminergic signals are an essential feature of the neural network responsible for instrumental reinforcement during discovery of an action. However, the timing of signals that are thought to contribute to the induction of corticostriatal plasticity is difficult to reconcile within the framework of behavioural reinforcement learning, because the reinforcer is normally delayed relative to the selection and execution of causally-related actions.

objectiveWhile recent studies have started to address the relevance of delayed reinforcement signals and their impact on corticostriatal processing, our objective was to establish a model in which a sensory reinforcer triggers appropriately delayed reinforcement signals relayed to the striatum via intact neuronal pathways and to investigate the effects on corticostriatal plasticity.

methodsWe measured corticostriatal plasticity with electrophysiological recordings using a light flash as a natural sensory reinforcer, and pharmacological manipulations were applied in an

resultsWe demonstrate that the spiking of striatal neurons evoked by single-pulse stimulation of the motor cortex can be potentiated by a natural sensory reinforcer, operating through intact afferent pathways, with signal timing approximating that required for behavioural reinforcement. The pharmacological blockade of dopamine receptors attenuated the observed potentiation of corticostriatal neurotransmission.

conclusionThis novel

Indexed as

Corpus StriatumNeuronal PlasticityReinforcement, PsychologyAnimalsMaleMotor CortexNeural PathwaysNeuronsRatsRats, Sprague-DawleyCorticostriataldopamineplasticityreinforcement.sensorytiming

Identifiers

PMID37533245
PMCPMC11097983

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.