Evidence map›Paper›PMID 37533073›Full record

ArticleCost effectiveness and resource allocation : C/E2023

Costs of fall injuries in the STRIDE study: an economic evaluation of healthcare system heterogeneity and heterogeneity of treatment effect.

David A Ganz, Thomas M Gill, David B Reuben, Shalender Bhasin, Nancy K Latham, Peter Peduzzi, Erich J Greene

Registry-linked trialAbstract read
In one paragraph

Article in Cost effectiveness and resource allocation : C/E, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02475850 (Randomized Trial of a Multifactorial Fall Injury Prevention Strategy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02475850 phase3completednot on this map

Randomized Trial of a Multifactorial Fall Injury Prevention Strategy

TypeinterventionalSponsorBrigham and Women's HospitalRan2015 to 2020Enrolled5,451ConditionsAccidental Falls, Wounds and InjuriesArmsEvidence-based tailored fall prevention, Usual care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David A GanzDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. dganz@mednet.ucla.edu.
Thomas M GillDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
David B ReubenDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Shalender BhasinBoston Claude D. Pepper Older Americans Independence Center, Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nancy K LathamBoston Claude D. Pepper Older Americans Independence Center, Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Peter PeduzziYale Center for Analytical Sciences, Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
Erich J GreeneYale Center for Analytical Sciences, Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Randomized Trial of a Multifactorial Fall Injury Prevention Strategy-SupplementU01AG048270 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER, GILL, THOMAS MICHAEL · 2014 to 2019
$34.8M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEWIS LIPSITZ · 2008 to 2026
$23.9M
Enhancing the Efficiency of Pragmatic Clinical Trials Using Administrative Data: Analysis of the STRIDE StudyR01AG071528 · NIA · YALE UNIVERSITY · PI ESSERMAN, DENISE, GANZ, DAVID · 2022 to 2025
$2.0M
NCATS NIH HHS UL1 TR001863NIA NIH HHS 5U01AG048270NIA NIH HHS P30 AG024824NIA NIH HHS P30 AG031679NIA NIH HHS R01 AG071528NIA NIH HHS U01 AG048270
6 · The paper itself

Abstract

objectivesThe Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) Study cluster-randomized 86 primary care practices in 10 healthcare systems to a patient-centered multifactorial fall injury prevention intervention or enhanced usual care, enrolling 5451 participants. We estimated total healthcare costs from participant-reported fall injuries receiving medical attention (FIMA) that were averted by the STRIDE intervention and tested for healthcare-system-level heterogeneity and heterogeneity of treatment effect (HTE).

methodsParticipants were community-dwelling adults age ≥ 70 at increased fall injury risk. We estimated practice-level total costs per person-year of follow-up (PYF), assigning unit costs to FIMA with and without an overnight hospital stay. Using independent variables for treatment arm, healthcare system, and their interaction, we fit a generalized linear model with log link, log follow-up time offset, and Tweedie error distribution.

resultsUnadjusted total costs per PYF were $2,034 (intervention) and $2,289 (control). The adjusted (intervention minus control) cost difference per PYF was -$167 (95% confidence interval (CI), -$491, $216). Cost heterogeneity by healthcare system was present (p = 0.035), as well as HTE (p = 0.090). Adjusted total costs per PYF in control practices varied from $1,529 to $3,684 for individual healthcare systems; one system with mean intervention minus control costs of -$2092 (95% CI, -$3,686 to -$944) per PYF accounted for HTE, but not healthcare system cost heterogeneity.

conclusionsWe observed substantial heterogeneity of healthcare system costs in the STRIDE study, with small reductions in healthcare costs for FIMA in the STRIDE intervention accounted for by a single healthcare system.

trial registrationClinicaltrials.gov (NCT02475850).

Indexed as

Economic evaluationFall preventionHeterogeneity of treatment effect

Identifiers

PMID37533073
PMCPMC10399038

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.