ArticleMolecular neurobiology2023
Hmox1 is Identified as a Ferroptosis Hub Gene and Associated with the M1 Type Microglia/Macrophage Polarization in Spinal Cord Injury: Bioinformatics and Experimental Validation.
Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Advances in ferroptosis and cuproptosis: implications for spinal cord injury.Molecular biology reports · 2026Review
- Blood-brain barrier-penetrant nanotherapy inhibits haem oxygenase-1-mediated ferroptosis for post-resuscitation neuroprotection.Nature communications · 2026Article
- Machine learning identifies key cells and therapeutic targets during ferroptosis after spinal cord injury.Neural regeneration research · 2026Article
- Macrophage polarization-related genes with potential causal roles in osteoporosis: a multi-omics Mendelian randomization study.Journal of orthopaedic surgery and research · 2026Article
- Ferroptosis-associated myeloid cell heterogeneity and inflammatory amplification following spinal cord injury.Frontiers in immunology · 2026Article
- Spatial transcriptomics on an expanded dataset at the brain-electrode interface: exploration of variability and identification of novel biomarkers.Frontiers in neuroscience · 2026Article
- Nanoplastics amplify 6PPD ocular toxicity in zebrafish.Environmental science and ecotechnology · 2026Article
- The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis.Acta pharmacologica Sinica · 2025Review
- Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury.Materials today. Bio · 2025Article
- Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies.MedComm · 2025Review
- SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ferroptosis and immune cell infiltration are important pathological events in spinal cord injury (SCI), but links between ferroptosis and immune microenvironment after SCI were rare reported. In our study, 77 FRDEGs were screened at 7 days after SCI. GO analysis of FRDEGs showed that aging (GO:0007568; P-value = 1.11E-05) was the most remarkable enriched for biological process, protein binding (GO:0005515; adjusted P-value = 4.44E-06) was the most significantly enriched for molecular function, cytosol (GO:0005829; adjusted P-value = 1.51E-04) was the most prominent enriched for cellular component. Meanwhile, Ferroptosis was significantly enriched both in KEGG (rno04216; adjusted P-value = 0.001) and GSEA (NES = 1.35; adjusted P-value = 0.004) analysis. Next, Hmox1 (Log
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