Evidence map›Paper›PMID 37532951›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2023

Aortic smooth muscle TRPV4 channels regulate vasoconstriction in high salt-induced hypertension.

Xin Wen, Yidi Peng, Yuefeng Peng, Yuzhong Zhu, Fan Yu, Li Geng, Tingting Zhou, Xianfeng Wang, Lei Feng, Qingyou Meng

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Transient Receptor Potential Vanilloid 4 (TRPV4) in the Human Carotid Body.International journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Hypertension research 2024 update and perspectives: basic research.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xin Wen *Wuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Yidi Peng *School of Pharmaceutical Sciences, Jiangnan University, Wuxi, 214000, China.
Yuefeng PengWuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Yuzhong ZhuWuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Fan YuWuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Li GengWuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Tingting ZhouWuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Xianfeng WangWuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Lei FengWuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Qingyou MengDepartment of Vascular Surgery, General Surgery Clinical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. mengqy@163.com.
Jiangnan University · CNShanghai Mental Health Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have focused on the contribution of vascular endothelial transient receptor potential vanilloid 4 (TRPV4) channels to hypertension. However, in hypertension, TRPV4 channels in vascular smooth muscle remain unexplored. In the present study, we performed wire myograph experiments in isolated aortas from endothelial cell specific TRPV4 channel knockout (TRPV4

Indexed as

AortaHypertensionTransient Receptor Potential ChannelsTRPV Cation ChannelsAnimalsMiceMuscle, Smooth, VascularMyocytes, Smooth MuscleSodium ChlorideSodium Chloride, DietaryVasoconstrictionSodium ChlorideSodium Chloride, DietaryTransient Receptor Potential ChannelsTrpv4 protein, mouseTRPV Cation ChannelsAortaContractionHypertensionSmooth muscleTransient receptor potential vanilloid 4 (TRPV4)

Identifiers

PMID37532951
OpenAlexW4385493659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.