ArticleNature2023
Africa-specific human genetic variation near CHD1L associates with HIV-1 load.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region.PLoS pathogens · 2026Article
- Novel attributes of HIV-1 elite controllers: redefining persistent HIV-1 remission.Current opinion in HIV and AIDS · 2026Article
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- BeyondFrontiers in genetics · 2026Review
- Kaposi's Sarcoma: A Non-Communicable Outcome Mainly Prompted by Communicable Diseases in Sub-Saharan Africa.International journal of molecular sciences · 2025Review
- Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant.Nucleic acids research · 2025Article
- A map of blood regulatory variation in South Africans enables GWAS interpretation.Nature genetics · 2025Article
- Functionally-informed fine-mapping identifies genetic variants linking increased CHD1L expression and HIV restriction in monocytes.Scientific reports · 2025Article
- Chromosome 1 variants associated with decreased HIV set-point viral load correlate with PRKAB2 expression changes.Frontiers in genetics · 2025Article
- Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules.Structure (London, England : 1993) · 2024Article
- Epistatic interaction between ERAP2 and HLA modulates HIV-1 adaptation and disease outcome in an Australian population.PLoS pathogens · 2024Article
- Review
- The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants.AIDS research and therapy · 2024Article
- Making genome editing a success story in Africa.Nature biotechnology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
71 authors.
Paul J McLaren *Sexually Transmitted and Blood-Borne Infections Division at JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. paul.mclaren@phac-aspc.gc.ca.ORCID 0000-0001-6019-7018
Immacolata Porreca *Wellcome Trust Sanger Institute, Hinxton, UK.
Gennaro Iaconis *Department of Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9830-3506
Hoi Ping Mok *Department of Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1402-7194
Subhankar Mukhopadhyay *Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK.
Emre Karakoc *Wellcome Trust Sanger Institute, Hinxton, UK.
Sara CristinelliInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Cristina PomillaWellcome Trust Sanger Institute, Hinxton, UK.
István BarthaGlobal Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Christian W ThorballGlobal Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6869-6943
Riley H ToughSexually Transmitted and Blood-Borne Infections Division at JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Paolo AngelinoSwiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0002-1037-2823
Cher S KiarPeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK.
Tommy CarstensenWellcome Trust Sanger Institute, Hinxton, UK.
Segun FatumoThe African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda.
Tarryn PorterWellcome Trust Sanger Institute, Hinxton, UK.ORCID 0000-0002-6063-0659
Isobel JarvisDepartment of Medicine, University of Cambridge, Cambridge, UK.
William C SkarnesThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Andrew BassettWellcome Trust Sanger Institute, Hinxton, UK.ORCID 0000-0003-1632-9137
Marianne K DeGorterDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7592-752X
Mohana Prasad Sathya MoorthyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Jeffrey F TuffSexually Transmitted and Blood-Borne Infections Division at JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Eun-Young KimDivision of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-7436-7396
Miriam WalterDivision of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lacy M SimonsDivision of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Arman BashirovaBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Susan BuchbinderBridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.ORCID 0000-0003-2404-0712
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0002-2692-2180
Andrea CossarizzaDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0002-5381-1558
Andrea De LucaUniversity Division of Infectious Diseases, Siena University Hospital, Siena, Italy.
James J GoedertEpidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
David B GoldsteinInstitute for Genomic Medicine, Columbia University, New York, NY, USA.ORCID 0000-0002-1111-2820
David W HaasDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Joshua T HerbeckDepartment of Global Health, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4577-7406
Eric O JohnsonGenOmics and Translational Research Center and Fellow Program, RTI International, Research Triangle Park, NC, USA.ORCID 0000-0002-8870-1949
Pontiano KaleebuMedical Research Council/Uganda Virus Research Institute & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda.
William KilembeCenter for Family Health Research-Zambia, Lusaka, Zambia.
Gregory D KirkDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-7829-1405
Neeltje A KootstraDepartment of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Alex H KralCommunity Health Research Division, RTI International, Berkeley, CA, USA.
Olivier LambotteUniversité Paris Saclay, Inserm UMR1184, CEA, Le Kremlin-Bicêtre, France.
Ma LuoDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.
Simon MallalDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Javier Martinez-PicadoUniversity of Vic-Central University of Catalonia, Vic, Spain.ORCID 0000-0002-4916-2129
Laurence MeyerINSERM U1018, Université Paris-Saclay, Le Kremlin Bicêtre, France.
José M MiroCIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.
Pravi MoodleyNational Health Laboratory Service, South Africa and University of KwaZulu-Natal, Durban, South Africa.
Ayesha A MotalaDepartment of Diabetes and Endocrinology, School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0003-0517-1784
James I MullinsDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Kireem NamDivision of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Niels ObelDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Fraser PirieDepartment of Diabetes and Endocrinology, School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
Francis A PlummerDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.
Guido PoliDivision of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
Matthew A PriceInternational AIDS Vaccine Initiative, New York, NY, USA.
Andri RauchDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-5297-6062
Ioannis TheodorouLaboratoire d'Immunologie, Hôpital Robert Debré Paris, Paris, France.
Alexandra TrkolaInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-1013-876X
Bruce D WalkerRagon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Cheryl A WinklerBasic Research Laboratory, Molecular Genetic Epidemiology Section, Frederick National Laboratory for Cancer Research and Cancer Innovative Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0001-5552-0917
Jean-François ZaguryLaboratoire Génomique, Bioinformatique et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Stephen B MontgomeryDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5200-3903
Angela CiuffiInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-2333-513X
Judd F HultquistDivision of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-6424-4280
Steven M WolinskyDivision of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Gordon DouganWellcome Trust Sanger Institute, Hinxton, UK.
Andrew M L LeverDepartment of Medicine, University of Cambridge, Cambridge, UK.
Deepti GurdasaniQueen Mary University of London, London, UK.ORCID 0000-0001-9996-6929
Harriet GroomDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0557-4583
Manjinder S SandhuDepartment of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK. m.sandhu@imperial.ac.uk.ORCID 0000-0002-2725-142X
Jacques FellayGlobal Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. jacques.fellay@epfl.ch.ORCID 0000-0002-8240-939X
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MLeadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1MStatistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6MMULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4MVirology and Immunology Technology CoreP30AI117943 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Mohamed Abdel Mohsen · 2015 to 2026
$38.4MProject 3U54AI170792 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$35.7MClinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7MUniversity of Pittsburgh MWCCS Clinical Research SiteU01HL146208 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bernard Jonas C Macatangay, CHARLES R RINALDO · 2019 to 2026
$32.2MStudy of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort StudyU01HL146333 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roger Detels, Matthew James Mimiaga · 2019 to 2026
$32.2MNorthwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS ResearchU01HL146240 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Frank J Palella, Valentina Stosor · 2019 to 2026
$31.5MH3ABioNet: informatics solutions for H3AfricaU24HG006941 · NHGRI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA · 2017 to 2021
$12.9MGene Network Identification and Integration (GNetii) Approach to Understanding the Biology Underlying HIV and Drug Abuse.R01DA051908 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JACOBSON, DANIEL A, JOHNSON, ERIC OTTO · 2020 to 2024
$3.4MMedical Research Council MC_UU_00033/1Medical Research Council MC_UU_00033/3Medical Research Council MR/N02043X/1Medical Research Council MR/S009752/1NCI NIH HHS 75N91019D00024NHGRI NIH HHS U24 HG006941NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI117943NIAID NIH HHS R01 AI165236NIAID NIH HHS U01 AI035039NIAID NIH HHS U54 AI170792NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIDA NIH HHS R01 DA051908Wellcome Trust
Abstract
HIV-1 remains a global health crisis
Indexed as
DNA-Binding ProteinsDNA HelicasesGenetic VariationHIV-1HIV InfectionsViral LoadAfricaAllelesCell LineChromosomes, Human, Pair 1HumansRNA, Long NoncodingVirus ReplicationCHD1L protein, humanDNA-Binding ProteinsDNA HelicasesRNA, Long Noncoding
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.