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ArticleInternational journal of clinical pharmacy2024

Medication exposure of the dyad patient-caregiver in Alzheimer's disease and related dementias: a cross-sectional study.

Teddy Novais, Soraya Qassemi, Philippe Cestac, Cécile McCambridge, Hélène Villars, Bertrand Decaudin, Mathilde Dambrine, Dominique Huvent-Grelle, Jean Roche, Denis Federico and 2 more

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Article in International journal of clinical pharmacy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Teddy NovaisPharmaceutical Unit, Department of Pharmacy, Charpennes Hospital, Hospices Civils de Lyon, University Hospital of Lyon, 69100, Villeurbanne, France. teddy.novais@chu-lyon.fr.
Soraya QassemiREIPO Team, La Grave Hospital, Toulouse University Hospital, 31000, Toulouse, France.
Philippe CestacDepartment of Pharmacy, Toulouse University Hospital, 31000, Toulouse, France.
Cécile McCambridgeDepartment of Pharmacy, Toulouse University Hospital, 31000, Toulouse, France.
Hélène VillarsCentre for Epidemiology and Population Health Research (CERPOP), UMR 1027, INSERM, University of Toulouse, 31000, Toulouse, France.
Bertrand DecaudinULR 7365-GRITA-Groupe de Recherche sur les Formes Injectables et les Technologies Associées, University Lille, 59000, Lille, France.
Mathilde DambrinePharmacie Institute, CHU Lille, 59000, Lille, France.
Dominique Huvent-GrelleGeriatric Department, CHU Lille, 59000, Lille, France.
Jean RocheDepartment of Geriatric Psychiatry, CHU Lille, 59000, Lille, France.
Denis FedericoLyon Institute for Aging, Hospices Civils de Lyon, 69000, Lyon, France.
Pierre Krolak-SalmonLyon Institute for Aging, Hospices Civils de Lyon, 69000, Lyon, France.
Christelle MouchouxPharmaceutical Unit, Department of Pharmacy, Charpennes Hospital, Hospices Civils de Lyon, University Hospital of Lyon, 69100, Villeurbanne, France.

Funding

Ministère de la Santé et des Services sociaux 14-0568
6 · The paper itself

Abstract

backgroundPatients with Alzheimer's disease and related dementias and their caregivers can be defined as people with higher risk of developing medication-related problems due to aging and polypharmacy.

aimTo assess the medication exposure of patient with Alzheimer's disease and related dementias and their caregivers.

methodAncillary cross-sectional study based on baseline medication data of the PHARMAID RCT. The PHARMAID study was a multi-center RCT assessing an integrated pharmaceutical care at a psychosocial program. Older outpatients with Alzheimer's disease and related dementias and their older caregivers were eligible for inclusion. Baseline medication data were used to assess the medication exposure, illustrated by the number of medications, the prevalence of potentially inappropriate medications (PIMs) using the EU(7)-PIM list and the Medication Regimen Complexity Index (MRCI).

resultsSeventy-three dyads were included in this ancillary study. The mean numbers (SD) of medications used by patients was 6.8 (2.6) and by caregivers was 4.7 (3.7). Overall, 60.3% of patients used at least one PIM and 47.9% of caregivers. Regarding the medication regimen complexity, the mean MRCI was 16.3(8.1) for patients and 11.3(10.5) for caregivers.

conclusionThe results of this study confirm the relevance of carrying out medication review with patients, but also with their caregivers who can be considered as hidden patients.

Indexed as

Alzheimer DiseaseCaregiversCross-Sectional StudiesHumansPotentially Inappropriate Medication ListPrevalenceAlzheimer’s diseaseCaregiversCross-sectional studyDementiasMedication regimen complexityPotentially inappropriate medication

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.