Evidence map›Paper›PMID 37532513›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Apolipoprotein E-associated Lipoprotein Glomerulo-tubulopathy.

Hikaru Tanimizu, Risa Hara, Akinari Sekine, Noriko Inoue, Eiko Hasegawa, Kiho Tanaka, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Minoru Okubo and 7 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hikaru TanimizuNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Risa HaraNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Akinari SekineNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Noriko InoueNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Eiko HasegawaNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Kiho TanakaNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Kei KonoDepartment of Pathology, Toranomon Hospital Toranomon, Japan.
Keiichi KinowakiDepartment of Pathology, Toranomon Hospital Toranomon, Japan.
Kenichi OhashiDepartment of Pathology, Toranomon Hospital Toranomon, Japan.
Minoru OkuboSection of Lipid Research and Department of Endocrinology and Metabolism, Toranomon Hospital, Japan.
Yutaka YamaguchiYamaguchi's Pathology Laboratory, Japan.
Dedong KangDepartment of Anatomy, Showa University School of Medicine, Japan.
Kazuho HondaDepartment of Anatomy, Showa University School of Medicine, Japan.
Takao SaitoSanko Clinic, Japan.
Naoki SawaNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Yoshifumi UbaraNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Junichi HoshinoNephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 32-year-old man was admitted for the evaluation of proteinuria (5.69 g/day). A light microscopic examination showed markedly dilated glomerular capillary loops with vacuolated areas in many glomeruli, and vacuolated areas were seen on peritubular capillaries in the tubulointerstitium. When electron microscopy specimens prepared by pre-fixation with glutaraldehyde and post-fixation with osmium tetroxide were used for oil red staining, the deposition was confirmed on the affected areas. A genetic analysis of apoE showed that the lipoprotein glomerulopathy was due to apoE-Sendai (Arg145Pro, p.R163P) heterozygosity, which was found in not only the patient but also his mother and twin brother.

Indexed as

Apolipoproteins EKidney DiseasesAdultHeterozygoteHumansKidney GlomerulusMaleProteinuriaApolipoproteins Eapolipoprotein Elipoprotein glomerulopathyoil red staining

Identifiers

PMID37532513
PMCPMC10465279

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.