Evidence map›Paper›PMID 37531957›Full record

ArticleCurrent biology : CB2023

Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information.

Olivier D Laflamme, Sergey N Markin, Dylan Deska-Gauthier, Rachel Banks, Ying Zhang, Simon M Danner, Turgay Akay

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  8. Sensory Feedback and Central Neuronal Interactions in Mouse Locomotion.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Olivier D LaflammeAtlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, NS B3T 0A6, Canada.
Sergey N MarkinDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, USA.
Dylan Deska-GauthierAtlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, NS B3T 0A6, Canada.
Rachel BanksAtlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, NS B3T 0A6, Canada.
Ying ZhangAtlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, NS B3T 0A6, Canada.
Simon M DannerDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, USA.
Turgay AkayAtlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, NS B3T 0A6, Canada. Electronic address: turgay.akay@dal.ca.
Dalhousie University · CADrexel University · US

Funding

Effect of GABAergic inhibition of dendritic spines on synaptic pruning in the medial prefrontal cortex during adolescenceR01MH115900 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SMITH, SHERYL S · 2019 to 2023
$3.2M
Spinal circuits for sensorimotor integration and interlimb coordination during locomotionR01NS115900 · NINDS · DREXEL UNIVERSITY · PI DANNER, SIMON MICHAEL · 2020 to 2024
$1.7M
NIMH NIH HHS R01 MH115900NINDS NIH HHS R01 NS115900
6 · The paper itself

Abstract

Crossed reflexes are mediated by commissural pathways transmitting sensory information to the contralateral side of the body, but the underlying network is not fully understood. Commissural pathways coordinating the activities of spinal locomotor circuits during locomotion have been characterized in mice, but their relationship to crossed reflexes is unknown. We show the involvement of two genetically distinct groups of commissural interneurons (CINs) described in mice, V0 and V3 CINs, in the crossed reflex pathways. Our data suggest that the exclusively excitatory V3 CINs are directly involved in the excitatory crossed reflexes and show that they are essential for the inhibitory crossed reflexes. In contrast, the V0 CINs, a population that includes excitatory and inhibitory CINs, are not directly involved in excitatory or inhibitory crossed reflexes but downregulate the inhibitory crossed reflexes. Our data provide insights into the spinal circuitry underlying crossed reflexes in mice, describing the roles of V0 and V3 CINs in crossed reflexes.

Indexed as

Commissural InterneuronsAnimalsLocomotionMiceSpinal Cordcommissural interneuroncrossed reflexinterlimb coordinationlocomotionmouse geneticssensory feedbacksensorymotor integrationspinal cordV0 interneuronsV3 interneurons

Identifiers

PMID37531957
PMCPMC10528931
OpenAlexW4385461623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.