ArticleNeuroImage. Clinical2023
Spatial patterns of gray and white matter compromise relate to age of seizure onset in temporal lobe epilepsy.
Article in NeuroImage. Clinical, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Alterations in glymphatic system and brain morphology in patients with temporal lobe epilepsy.BMC medical imaging · 2026Article
- Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery.Epilepsia · 2025Article
- Superficial and deep white matter abnormalities in temporal lobe epilepsy.Brain communications · 2025Article
- A WORLDWIDE ENIGMA STUDY ON EPILEPSY-RELATED GRAY AND WHITE MATTER COMPROMISE ACROSS THE ADULT LIFESPAN.bioRxiv : the preprint server for biology · 2024Article
- Adding the third dimension: 3D convolutional neural network diagnosis of temporal lobe epilepsy.Brain communications · 2024Article
- Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study.Frontiers in neuroscience · 2024Article
- Out of one, how many? Subtyping in epilepsy.Brain : a journal of neurology · 2023Article
- The cumulative impact of seizures: the science underlying how seizures beget seizures.Frontiers in neurologyReview
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTemporal Lobe Epilepsy (TLE) is frequently a neurodevelopmental disorder, involving subcortical volume loss, cortical atrophy, and white matter (WM) disruption. However, few studies have addressed how these pathological changes in TLE relate to one another. In this study, we investigate spatial patterns of gray and white matter degeneration in TLE and evaluate the hypothesis that the relationship among these patterns varies as a function of the age at which seizures begin.
methodsEighty-two patients with TLE and 59 healthy controls were enrolled. T1-weighted images were used to obtain hippocampal volumes and cortical thickness estimates. Diffusion-weighted imaging was used to obtain fractional anisotropy (FA) and mean diffusivity (MD) of the superficial WM (SWM) and deep WM tracts. Analysis of covariance was used to examine patterns of WM and gray matter alterations in TLE relative to controls, controlling for age and sex. Sliding window correlations were then performed to examine the relationships between SWM degeneration, cortical thinning, and hippocampal atrophy across ages of seizure onset.
resultsCortical thinning in TLE followed a widespread, bilateral pattern that was pronounced in posterior centroparietal regions, whereas SWM and deep WM loss occurred mostly in ipsilateral, temporolimbic regions compared to controls. Window correlations revealed a relationship between hippocampal volume loss and whole brain SWM disruption in patients who developed epilepsy during childhood. On the other hand, in patients with adult-onset TLE, co-occurring cortical and SWM alterations were observed in the medial temporal lobe ipsilateral to the seizure focus. SIGNIFICANCE: Our results suggest that although cortical, hippocampal and WM alterations appear spatially discordant at the group level, the relationship among these features depends on the age at which seizures begin. Whereas neurodevelopmental aspects of TLE may result in co-occurring WM and hippocampal degeneration near the epileptogenic zone, the onset of seizures in adulthood may set off a cascade of SWM microstructural loss and cortical atrophy of a neurodegenerative nature.
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