ArticleScience advances2023
Single-cell atlases of two lophotrochozoan larvae highlight their complex evolutionary histories.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Distinct cell states define larval and adult body plans in a hemichordate.Nature communications · 2026Article
- Pesci: fast and user-friendly software to compare single-cell gene expression across species.Bioinformatics (Oxford, England) · 2026Article
- Multiple evolutionary routes to immune diversification across animals.International immunology · 2026Review
- Extreme conservation of cnidarian stinging cell identity despite 600 million years of evolution.bioRxiv : the preprint server for biology · 2026Article
- The 3D architecture of the ctenophore aboral organ and the evolution of complex integrative centers in animals.Science advances · 2026Article
- Evolutionary innovation within conserved gene regulatory networks underlying biomineralized skeletons in Bilateria.Molecular biology and evolution · 2026Article
- Article
- Single-nucleus profiling highlights the all-brain echinoderm nervous system.Science advances · 2025Article
- Primordial germ cell specification and early developmental cell states in Pacific oyster.BMC genomics · 2025Article
- Spontaneous ectopic head formation enables reversal of the body axis polarity in microscopic flatworms.Proceedings. Biological sciences · 2025Article
- Establishing single cell RNA transcriptomics: a brief guide.Frontiers in zoology · 2025Review
- Article
- Applications and techniques of single-cell RNA sequencing across diverse species.Briefings in bioinformatics · 2025Review
- An ancient apical patterning system sets the position of the forebrain in chordates.Science advances · 2025Article
- Opsin expression varies across larval development and taxa in pteriomorphian bivalves.Frontiers in neuroscience · 2024Article
- Marine Invertebrates One Cell at A Time: Insights from Single-Cell Analysis.Integrative and comparative biology · 2023Review
- Convergent evolution of the sensory pits in and within flatworms.BMC biology · 2023Article
- Functional genomics in Spiralia.Briefings in functional genomics · 2023Article
- Single-cell transcriptomics refuels the exploration of spiralian biology.Briefings in functional genomics · 2023Review
- Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians.Briefings in functional genomics · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pelagic larval stages are widespread across animals, yet it is unclear whether larvae were present in the last common ancestor of animals or whether they evolved multiple times due to common selective pressures. Many marine larvae are at least superficially similar; they are small, swim through the beating of bands of cilia, and sense the environment with an apical organ. To understand these similarities, we have generated single-cell atlases for marine larvae from two animal phyla and have compared their cell types. We found clear similarities among ciliary band cells and between neurons of the apical organ in the two larvae pointing to possible homology of these structures, suggesting a single origin of larvae within Spiralia. We also find several clade-specific innovations in each larva, including distinct myocytes and shell gland cells in the oyster larva. Oyster shell gland cells express many recently evolved genes that have made previous gene age estimates for the origin of trochophore larvae too young.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.