ArticleScience translational medicine2023
Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans.
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Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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20 citing papers in PubMed, 24 citations in OpenAlex.
- Integrated single-cell multiomics reveals neutrophil-driven immune-metabolic reprogramming of Kupffer cells via thrombospondin-1/CD36 after surgical stress.JCI insight · 2026Article
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- The post-transcriptional regulatory RNA-binding protein PTBP1 functions as an inhibitor in hepatic stellate cell activation and liver fibrosis.Molecular medicine (Cambridge, Mass.) · 2026Article
- PTBP1 is upregulated in response to Zika virus infection and restrains viral replication by hijacking viral NS1 protein to induce NS1 degradation.Journal of virology · 2026Article
- Alternative Splicing: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets.MedComm · 2025Review
- Hepatic ischemia-reperfusion injury: Underlying mechanisms and concepts in liver surgery and liver transplantation.Hepatology (Baltimore, Md.) · 2025Article
- Hypoxia-mediated regulation of mRNA metabolism: from transcription to stability.Cell communication and signaling : CCS · 2025Review
- Posttranscriptional control of hepatic CEACAM1 3'UTR by human antigen R (HuR) mitigates sterile liver inflammation.JCI insight · 2025Article
- Feedback Loops Shape Oxidative and Immune Interactions in Hepatic Ischemia-Reperfusion Injury.Antioxidants (Basel, Switzerland) · 2025Review
- Direct RNA sequencing reveals chicken post-transcriptional modifications in response to Campylobacter jejuni inoculation.BMC genomics · 2025Article
- Comprehensive analysis of immunogenic cell death-related genes in liver ischemia-reperfusion injury.Frontiers in immunology · 2025Article
- Genome-wide analysis of alternative splicing differences in hepatic ischemia reperfusion injury.Scientific reports · 2024Article
- Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany.European journal of clinical investigation · 2024Article
- Mechanism and function of CEACAM1 splice isoforms.European journal of clinical investigation · 2024Review
- Mechanistic Insights into Alternative Gene Splicing in Oxidative Stress and Tissue Injury.Antioxidants & redox signaling · 2024Review
- Current status and perspective on molecular targets and therapeutic intervention strategy in hepatic ischemia-reperfusion injury.Clinical and molecular hepatology · 2024Review
- The Coming Age of Antisense Oligos for the Treatment of Hepatic Ischemia/Reperfusion (IRI) and Other Liver Disorders: Role of Oxidative Stress and Potential Antioxidant Effect.Antioxidants (Basel, Switzerland) · 2024Review
- Steatotic Donor Transplant Livers: Preservation Strategies to Mitigate against Ischaemia-Reperfusion Injury.International journal of molecular sciences · 2024Review
- Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Kenneth J DeryDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0003-4238-4092
Hidenobu KojimaDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Shoichi KageyamaDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0002-2398-2428
Kentaro KadonoDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Hirofumi HiraoDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0001-6975-2436
Brian ChengDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Yuan ZhaiDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Douglas G FarmerDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0001-9080-0527
Fady M KaldasDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0002-4888-3979
Xiaoyi YuanDepartment of Anesthesiology, McGovern Medical School at UTHealth, Houston, TX 77030, USA.ORCID 0000-0002-2898-6495
Holger K EltzschigDepartment of Anesthesiology, McGovern Medical School at UTHealth, Houston, TX 77030, USA.
Jerzy W Kupiec-WeglinskiDivision of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0001-8976-4872
University of California, Los Angeles · USThe University of Texas Health Science Center · US
Funding
Regulation of Innate Immune Responses by Alloimmunity in Liver Ischemia-Reperfusion InjuryP01AI120944 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELAINE F REED · 2017 to 2026
$20.0MNRF2 - SIRT1 SIGNALING AXIS IN LIVER TRANSPLANT REJUVENATIONR01DK062357 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUPIEC-WEGLINSKI, JERZY W · 2003 to 2025
$8.4MmicroRNA miR-147 Dampens Alveolar Epithelial Inflammation During ARDSR01HL154720 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2021 to 2024
$2.2MTargeting Myeloid Dependent MicroRNAs in Acute Respiratory Distress SyndromeR01HL155950 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Xiaoyi Yuan · 2022 to 2026
$2.0MTHE RELAXIN RECEPTOR GR/RXFP1 SIGNALING IN LIVER TRANSPLANT ISCHEMIA-REPERFUSION INJURY AND THE INFLAMMATION RESOLUTIONR01AI155856 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUPIEC-WEGLINSKI, JERZY W · 2020 to 2024
$1.9MTargeting MicroRNA miR-122 for the Treatment of Perioperative Liver InjuryR01DK122796 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2020 to 2023
$1.8MTIM-3 Negative Costimulation Signaling at the Innate-Adaptive Immune interface in Liver Transplant Ischemia-Reperfusion InjuryR01DK107533 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUPIEC-WEGLINSKI, JERZY W · 2016 to 2020
$1.7MTim Costimulation in Liver Transplant Ischemia InjuryR01DK102110 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUPIEC-WEGLINSKI, JERZY W · 2015 to 2019
$1.7MMicroRNA Shuttling during Acute Respiratory Distress SyndromeR01HL133900 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2017 to 2020
$1.5MNHLBI NIH HHS R01 HL133900NHLBI NIH HHS R01 HL154720NHLBI NIH HHS R01 HL155950NIAID NIH HHS P01 AI120944NIAID NIH HHS R01 AI155856NIDDK NIH HHS R01 DK062357NIDDK NIH HHS R01 DK102110NIDDK NIH HHS R01 DK107533NIDDK NIH HHS R01 DK122796
Abstract
Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to environmental stresses, its contributions in organ transplantation have not been appreciated. We have shown that carcinoembryonic antigen-related cell adhesion molecule (Ceacam1;
Indexed as
Liver DiseasesLiver TransplantationAlternative SplicingAnimalsAntigens, CDCell Adhesion MoleculesHumansHypoxia-Inducible Factor 1, alpha SubunitIschemiaLiving DonorsMiceAntigens, CDCD66 antigensCell Adhesion MoleculesHypoxia-Inducible Factor 1, alpha Subunit
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