Evidence map›Paper›PMID 37531295›Full record

ArticleAnaesthesia2023

Postoperative systemic inflammation after major abdominal surgery: patient-centred outcomes.

C R Bain, P S Myles, C Martin, S Wallace, M A Shulman, T Corcoran, R Bellomo, P Peyton, D A Story, K Leslie and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Inflammatory Stewardship-A Perspective for Active Management of Acute Inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Review
  13. Patient Blood Management (PBM) as a Pillar in Surgical Safety and Care.Revista do Colegio Brasileiro de Cirurgioes · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

C R BainDepartment of Anaesthesiology and Peri-operative Medicine, Alfred Hospital and Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-3142-5410
P S MylesDepartment of Anaesthesiology and Peri-operative Medicine, Alfred Hospital and Monash University, Melbourne, VIC, Australia.
C MartinSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
S WallaceDepartment of Anaesthesiology and Peri-operative Medicine, Alfred Hospital and Monash University, Melbourne, VIC, Australia.
M A ShulmanDepartment of Anaesthesiology and Peri-operative Medicine, Alfred Hospital and Monash University, Melbourne, VIC, Australia.
T CorcoranDepartment of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth, WA, Australia.
R BellomoDepartment of Critical Care, University of Melbourne, Melbourne, VIC, Australia.
P PeytonDepartment of Anaesthesia, Austin Hospital, Heidelberg, VIC, Australia.
D A StoryDepartment of Critical Care, University of Melbourne, Melbourne, VIC, Australia.
K LeslieDepartment of Critical Care, University of Melbourne, Melbourne, VIC, Australia.
A ForbesSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
RELIEF trial investigators
The Alfred Hospital · AUMonash University · AUThe University of Melbourne · AUAustin Hospital · AURoyal Perth Hospital · AUThe Royal Melbourne Hospital · AU

Funding

National Health and Medical Research Council 1043755
6 · The paper itself

Abstract

Postoperative systemic inflammation is strongly associated with surgical outcomes, but its relationship with patient-centred outcomes is largely unknown. Detection of excessive inflammation and patient and surgical factors associated with adverse patient-centred outcomes should inform preventative treatment options to be evaluated in clinical trials and current clinical care. This retrospective cohort study analysed prospectively collected data from 3000 high-risk, elective, major abdominal surgery patients in the restrictive vs. liberal fluid therapy for major abdominal surgery (RELIEF) trial from 47 centres in seven countries from May 2013 to September 2016. The co-primary endpoints were persistent disability or death up to 90 days after surgery, and quality of recovery using a 15-item quality of recovery score at days 3 and 30. Secondary endpoints included: 90-day and 1-year all-cause mortality; septic complications; acute kidney injury; unplanned admission to intensive care/high dependency unit; and total intensive care unit and hospital stays. Patients were assigned into quartiles of maximum postoperative C-reactive protein concentration up to day 3, after multiple imputations of missing values. The lowest (reference) group, quartile 1, C-reactive protein ≤ 85 mg.l

Indexed as

C-Reactive ProteinPostoperative ComplicationsAbdomenHumansInflammationRetrospective StudiesC-Reactive Proteinanaesthesiadisability-free survivalmajor surgerypatient-reported outcomesquality of recoverysystemic inflammation

Identifiers

PMID37531295
PMCPMC10952313
OpenAlexW4385490355

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.