Evidence map›Paper›PMID 37530966›Full record

ArticleMolecular imaging and biology2024

2

Mir Hadi Razeghi Kondelaji, Guru Prasad Sharma, Jaidip Jagtap, Shayan Shafiee, Christopher Hansen, Tracy Gasperetti, Anne Frei, Dana Veley, Jayashree Narayanan, Brian L Fish and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Mir Hadi Razeghi Kondelaji *Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.
Guru Prasad Sharma *Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Jaidip JagtapDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Shayan ShafieeDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.
Christopher HansenDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.
Tracy GasperettiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Anne FreiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Dana VeleyDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Jayashree NarayananDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Brian L FishDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Abdul K ParchurDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
El-Sayed H IbrahimDepartment of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Meetha MedhoraDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Heather A HimburgDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. hhimburg@mcw.edu.
Amit JoshiDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA. ajoshi@mcw.edu.
Medical College of Wisconsin · USMayo Clinic in Arizona · US

Funding

Leveraging genetic mapping for personalized targeting of breast cancer microenvironmentR01CA193343 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amit Joshi · 2015 to 2026
$3.5M
Dkk1-Endothelial Progenitor Cell Treatment for the Mitigation of Hematopoietic Radiation InjuryU01AI138331 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HIMBURG, HEATHER A · 2018 to 2022
$3.0M
Mechanism of radiation induced endovascular injury and mitigation via the Notch-Dll4 pathwayU01AI133594 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI HIMBURG, HEATHER A · 2018 to 2022
$3.0M
NCI NIH HHS R01 CA193343NIAID NIH HHS U01 AI133594NIAID NIH HHS U01 AI138331NIH/NCI 2R01CA193343NIH/NIAID U01AI133594NIH/NIAID U01AI138331
6 · The paper itself

Abstract

purposeVascular endothelium plays a central role in the pathogenesis of acute and chronic radiation injuries, yet the mechanisms which promote sustained endothelial dysfunction and contribute to late responding organ failure are unclear. We employed 2 PROCEDURES: Consomic strains of female Salt Sensitive or SS (Dll4-high) and SS with 3

resultsWe show that SS.BN3 (Dll4-low) rats are relatively protected from vascular permeability disruption compared to the SS (Dll4-high) strain. We further demonstrated that SS.BN3 (Dll4-low) rats have reduced radiation induced loss of CD31

conclusionsTogether, these data suggest Dll4 plays a key role in pathogenesis of radiation-induced vascular injury to the lung and kidney.

Indexed as

Membrane ProteinsRadiation InjuriesVascular System InjuriesAnimalsEndothelial CellsFemaleIntracellular Signaling Peptides and ProteinsRatsdelta proteinIntracellular Signaling Peptides and ProteinsMembrane ProteinsConsomic rat modelDelta-like ligand 4 (Dll4)Indocyanine green (ICG)Near-infrared (NIR) fluorescence imagingNIR-1 windowNIR-2 windowVascular permeability

Identifiers

PMID37530966
PMCPMC11188939
OpenAlexW4385476306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.