ArticleWorld journal of urology2023
Computer tomography-based shape of tumor contour and texture of tumor heterogeneity are independent prognostic indicators for clinical T1b-T2 renal cell carcinoma.
Article in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Preoperative Tumor Shape Irregularity Is Associated With Pathological Upstaging to pT3 in Clinical T1 Renal Cell Carcinoma Treated With Partial or Radical Nephrectomy.International journal of urology : official journal of the Japanese Urological Association · 2026Article
- MRI In Vivo Detection of Amyloid-β Protein Deposition in Different Brain Regions of Patients with AD and MCI.Brain topography · 2026Article
- A preoperative CT-based radiological score for predicting recurrence in papillary renal cell carcinoma: a multicenter validation study.Insights into imaging · 2025Article
- Development and validation of a CT algorithm based on intratumoral necrosis and tumor morphology to predict the nuclear grade of small (2-4 cm) solid clear cell renal cell carcinoma.BMC medical imaging · 2025Article
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9 authors.
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Abstract
purposeTo evaluate association between computer tomography (CT)-based features of renal cell carcinoma (RCC) and survival outcomes.
methodsData of 958 patients with clinical T1b-T2 RCC who underwent partial/radical nephrectomy from June 2003 to March 2022 were retrospectively evaluated. CT images of patients were reviewed by two radiologists for texture analysis of tumor heterogeneity and shape analysis of tumor contour. Patients were divided into three groups according to patterns of CT-based features: (1) favorable feature group (n = 117); (2) intermediate feature group (n = 606); and (3) unfavorable feature group (n = 235). Kaplan-Meier survival analysis and multivariate Cox regression analysis were performed to evaluate overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS).
resultsRCCs with unfavorable CT-based feature showed larger size on CT, higher nuclear grade, higher rate of histologic necrosis, and higher rate of capsular invasion than those in the other two groups (all p < 0.001). Unfavorable feature was associated with poorer OS (p = 0.001), CSS (p < 0.001), and RFS (p < 0.001) on Kaplan-Meier analysis. In multivariate analysis, intermediate and unfavorable features were independent predictors for recurrence (hazard ratio [HR] 2.51, 95% confidence interval [CI] 1.09-5.79, p = 0.031 and HR 3.71, 95% CI 1.58-8.73, p = 0.003, respectively), but not for overall death or RCC-specific death.
conclusionsA combination of irregular tumor contour feature with heterogeneous tumor texture feature on CT is associated with poor RFS in clinical T1b-T2 RCC preoperatively.
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