Evidence map›Paper›PMID 37530575›Full record

ArticleACS nano2023

Multifunctional Calcium-Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment.

Guanghong Luo, Xing Li, Jihui Lin, Gao Ge, Jiangli Fang, Wangze Song, Gary Guishan Xiao, Bo Zhang, Xiaojun Peng, Yanhong Duo and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 102 citations in OpenAlex.

  1. Review
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  12. pH-responsive CaCOiScience · 2026
    Article
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  17. Next Generation Calcium Nanomaterials: Disrupting Tumor CaInternational journal of nanomedicine · 2026
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Guanghong LuoSchool of Medicine, The 2nd Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, P.R. China.
Xing LiSchool of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.
Jihui LinSchool of Medicine, The 2nd Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, P.R. China.
Gao GeDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Jiangli FangDepartment of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, 171 77, Sweden.
Wangze SongState Key Laboratory of Fine Chemicals, Department of Pharmacology, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
Gary Guishan XiaoResearch Center for Cancer Metabolism, College of Pharmacology, Shenzhen University of Technology, Chinese Academy of Sciences, Shenzhen, 518118, China.
Bo ZhangSchool of Medicine, The 2nd Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, P.R. China.
Xiaojun PengState Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
Yanhong DuoDepartment of Radiation Oncology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong China.ORCID 0000-0003-4569-0933
Ben Zhong TangShenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen. Shenzhen 518172, Guangdong China.
Dalian University of Technology · CNJinan University · CNShenzhen University · CNCentral South University · CNChinese University of Hong Kong, Shenzhen · CNKarolinska Institutet · SESouthern University of Science and Technology · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ions play a vital role in regulating various biological processes, including metabolic and immune homeostasis, which involves tumorigenesis and therapy. Thus, the perturbation of ion homeostasis can induce tumor cell death and evoke immune responses, providing specific antitumor effects. However, antitumor strategies that exploit the effects of multiion perturbation are rare. We herein prepared a pH-responsive nanomodulator by coloading curcumin (CU, a Ca

Indexed as

NanoparticlesNeoplasmsCalciumCell Line, TumorHumansHydrogen PeroxideImmunotherapyManganeseManganese CompoundsOxidesTumor MicroenvironmentCalciumHydrogen PeroxideManganeseManganese CompoundsOxidesantitumor therapycalcium−manganese nanomodulatorimmunotherapyreprogrammingtumor microenvironment

Identifiers

PMID37530575
PMCPMC10448754
OpenAlexW4385476417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.