ArticlePlant biotechnology journal2023
Engineering homoeologs provide a fine scale for quantitative traits in polyploid.
Article in Plant biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum.Plant biotechnology journal · 2026Article
- Winning by Losing: Exploiting Modified Plant Susceptibility Genes to Counteract Necrotrophic Fungal Pathogens.Plant biotechnology journal · 2025Review
- An efficient system for plastid transformation in an edible medicinal herb.Transgenic research · 2025Article
- Precise customization of plant architecture by combinatorial genetic modification of peptide ligands.Plant communications · 2025Article
- An Improved and SimplifiedPlants (Basel, Switzerland) · 2024Article
- Optimization of CRISPR-Cas9 system iniScience · 2024Article
- Genomic evidence for rediploidization and adaptive evolution following the whole-genome triplication.Nature communications · 2024Article
- Chromosome-scale assembly and gene editing of Solanum americanum genome reveals the basis for thermotolerance and fruit anthocyanin composition.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
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Authors and funding
27 authors.
Funding
Abstract
Numerous staple crops exhibit polyploidy and are difficult to genetically modify. However, recent advances in genome sequencing and editing have enabled polyploid genome engineering. The hexaploid black nightshade species Solanum nigrum has immense potential as a beneficial food supplement. We assembled its genome at the scaffold level. After functional annotations, we identified homoeologous gene sets, with similar sequence and expression profiles, based on comparative analyses of orthologous genes with close diploid relatives Solanum americanum and S. lycopersicum. Using CRISPR-Cas9-mediated mutagenesis, we generated various mutation combinations in homoeologous genes. Multiple mutants showed quantitative phenotypic changes based on the genotype, resulting in a broad-spectrum effect on the quantitative traits of hexaploid S. nigrum. Furthermore, we successfully improved the fruit productivity of Boranong, an orphan cultivar of S. nigrum suggesting that engineering homoeologous genes could be useful for agricultural improvement of polyploid crops.
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