ArticleeLife2023
Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Diversity and distribution of bacterial DNA polymerases.Nucleic acids research · 2026Article
- Identification of determinants of high-fidelity DNA synthesis in Mycobacterium smegmatis DnaE1 through in silico and in vivo approaches.Nucleic acids research · 2025Article
- Expression ofFrontiers in cellular and infection microbiology · 2025Article
- Article
- A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase inbioRxiv : the preprint server for biology · 2024Article
- Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome.eLife · 2023Article
- RecA-NT homology motif in ImuB is essential for mycobacterial ImuA'-ImuB protein interaction and mutasome function.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 9 institutions in 9 countries.
Sophia Gessner *SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0824-0079
Zela Alexandria-Mae Martin *SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Michael A Reiche *SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Joana A SantosDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
Ryan DinkeleSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Atondaho RamudzuliSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Neeraj DharLaboratory of Microbiology and Microsystems, School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0002-5887-8137
Timothy J de WetSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-3978-5322
Saber AnooshehSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Dirk M LangConfocal and Light Microscope Imaging Facility, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Jesse AaronAdvanced Imaging Center, Howard Hughes Medical Institute, Ashburn, United States.
Teng-Leong ChewAdvanced Imaging Center, Howard Hughes Medical Institute, Ashburn, United States.
Jennifer HerrmannHelmholtz Centre for Infection Research, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.
Rolf MüllerHelmholtz Centre for Infection Research, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.ORCID 0000-0002-1042-5665
John D McKinneyLaboratory of Microbiology and Microsystems, School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0002-0557-3479
Roger WoodgateLaboratory of Genomic Integrity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States.ORCID 0000-0001-5581-4616
Valerie MizrahiSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4824-9115
Česlovas VenclovasInstitute of Biotechnology, Vilnius University, Vilnius, Lithuania.
Meindert H LamersDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-4205-1338
Digby F WarnerSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-4146-0930
South African Medical Research Council · ZAGerman Center for Infection Research · DEHoward Hughes Medical Institute · USLeiden University Medical Center · NLÉcole Polytechnique Fédérale de Lausanne · CHEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Cape Town · ZAUniversity of Saskatchewan · CAVilnius University · LT
Funding
DNA Replication, Repair, and Mutagenesis In Eukaryotic And Prokaryotic CellsZIAHD001500 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI WOODGATE, ROGER · 2009 to 2025
$37.5MReplisome dynamics in M tuberculosis_linking persistence to genetic resistanceU01HD085531 · NICHD · UNIVERSITY OF CAPE TOWN · PI WARNER, DIGBY FRANCIS, WOODGATE, ROGER · 2015 to 2019
$1.1MHoward Hughes Medical Institute Senior International Research ScholarsNICHD NIH HHS U01 HD085531
Abstract
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in
Indexed as
Bacterial ProteinsMycobacterium tuberculosisAntitubercular AgentsDNA RepairMutagenesisAntitubercular AgentsBacterial Proteinsantibiotic resistanceanti-evolutionbiochemistrychemical biologyinduced mutagenesisinfectious diseasemicrobiologymutasomeMycobacterium smegmatisMycobacterium tuberculosis
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.