Evidence map›Paper›PMID 37530226›Full record

ArticleImmunology2023

Inhibition of PI3K p110δ activity reduces IgE production in IL-4 and anti-CD40 stimulated human B cell cultures.

Anna Cutrina-Pons, Aloka De Sa, David J Fear, Hannah J Gould, Faruk Ramadani

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. TThe Journal of allergy and clinical immunology · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna Cutrina-PonsRandall Centre for Cell & Molecular Biophysics, King's College London, London, UK.
Aloka De SaRandall Centre for Cell & Molecular Biophysics, King's College London, London, UK.ORCID 0000-0002-7714-8906
David J FearDivision of Asthma, Allergy and Lung Biology, King's College London, London, UK.
Hannah J GouldRandall Centre for Cell & Molecular Biophysics, King's College London, London, UK.
Faruk RamadaniRandall Centre for Cell & Molecular Biophysics, King's College London, London, UK.ORCID 0000-0001-8228-4868
King's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphoinositide 3-kinase (PI3K) p110δ signalling negatively regulates the production of mouse IgE. However, there are disparities between the mouse and human IgE biology, and the role of PI3K p110δ in the production of human IgE is yet to be determined. To investigate the effect of PI3K p110δ inhibition in the production of human IgE we isolated human B cells from tonsil tissue and stimulated them with IL-4 and anti-CD40 antibody to induce class switching to IgE and IgG1 in the presence or absence of IC87114, a small molecule inhibitor of PI3K p110δ. Using FACS, RT-PCR and ELISA we examined the effect of PI3K p110δ inhibition on IgE production and determined the mechanisms involved. Unlike in mice, we observed that PI3K p110δ inhibition significantly reduces the number of IgE

Indexed as

Interleukin-4Phosphatidylinositol 3-KinasesAnimalsCD40 AntigensCell Culture TechniquesHumansImmunoglobulin EImmunoglobulin GMiceCD40 AntigensImmunoglobulin EImmunoglobulin GInterleukin-4Phosphatidylinositol 3-Kinasesallergyclass-switchinghuman B cellsIgEp110δsignal transductionphosphoinositide 3-kinases

Identifiers

PMID37530226
PMCPMC11495259
OpenAlexW4385476028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.