Evidence map›Paper›PMID 37530209›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Deep Learning Enhanced Volumetric Photoacoustic Imaging of Vasculature in Human.

Wenhan Zheng, Huijuan Zhang, Chuqin Huang, Varun Shijo, Chenhan Xu, Wenyao Xu, Jun Xia

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  3. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wenhan ZhengDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York, NY, 14260, USA.
Huijuan ZhangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York, NY, 14260, USA.
Chuqin HuangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York, NY, 14260, USA.
Varun ShijoDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York, NY, 14260, USA.
Chenhan XuDepartment of Computer Science and Engineering, University at Buffalo, The State University of New York, Buffalo, New York, NY, 14260, USA.
Wenyao XuDepartment of Computer Science and Engineering, University at Buffalo, The State University of New York, Buffalo, New York, NY, 14260, USA.
Jun XiaDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York, NY, 14260, USA.ORCID 0000-0002-9864-7835
University at Buffalo, State University of New York · US

Funding

Development of photoacoustic tomography for non-invasive, label-free imaging of tissue perfusion in chronic woundsR01EB028978 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI XIA, JUN · 2021 to 2024
$1.6M
Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal viewR01EB029596 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI XIA, JUN · 2020 to 2023
$1.4M
NIBIB NIH HHS R01 EB028978NIBIB NIH HHS R01 EB029596NIH HHS R01EB028978NIH HHS R01EB029596
6 · The paper itself

Abstract

The development of high-performance imaging processing algorithms is a core area of photoacoustic tomography. While various deep learning based image processing techniques have been developed in the area, their applications in 3D imaging are still limited due to challenges in computational cost and memory allocation. To address those limitations, this work implements a 3D fully-dense (3DFD) U-net to linear array based photoacoustic tomography and utilizes volumetric simulation and mixed precision training to increase efficiency and training size. Through numerical simulation, phantom imaging, and in vivo experiments, this work demonstrates that the trained network restores the true object size, reduces the noise level and artifacts, improves the contrast at deep regions, and reveals vessels subject to limited view distortion. With these enhancements, 3DFD U-net successfully produces clear 3D vascular images of the palm, arms, breasts, and feet of human subjects. These enhanced vascular images offer improved capabilities for biometric identification, foot ulcer evaluation, and breast cancer imaging. These results indicate that the new algorithm will have a significant impact on preclinical and clinical photoacoustic tomography.

Indexed as

Deep LearningPhotoacoustic TechniquesHumansImage Processing, Computer-AssistedImaging, Three-DimensionalTomography, X-Ray Computed3D vascular Imagingdeep learninglinear transducer arraysphotoacoustic tomography

Identifiers

PMID37530209
PMCPMC10582405
OpenAlexW4385477380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.