Evidence map›Paper›PMID 37530129›Full record

ArticleHistology and histopathology2024

Long non-coding RNA BRE-AS1 inhibits proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating miR-106b-5p.

Gaode Zou, Lian Guo, Shaochen Shen, Zhen Song, Zheying Ouyang, Yi Yu

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Article in Histology and histopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gaode ZouDepartment of Urology, the Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, PR China.
Lian GuoDepartment of Anesthesia, the Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, PR China.
Shaochen ShenDepartment of Urology, the Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, PR China.
Zhen SongDepartment of Urology, the Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, PR China.
Zheying OuyangDepartment of Urology, the Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, PR China.
Yi YuDepartment of Urology, the Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, PR China. YiYuNanchang@163.com.

Funding

Jiangsu Youth Medical Talents Project Fund QNRC2016358
6 · The paper itself

Abstract

objectiveThe objective of this study was to investigate the involvement of the long non-coding RNA (lncRNA) BRE-AS1 in clear cell renal cell carcinoma (ccRCC) and to explore its potential therapeutic role.

methodsThe expression of BRE-AS1 and miR-106b-5p was determined by qRT-PCR. Overexpression of BRE-AS1 and miR-106b-5p were performed to study their relationship. Transwell assays were used to evaluate cell movement. Methylation-specific PCR (MSP) was performed to explore the role of BRE-AS1 in the methylation of the miR-106b-5p gene.

resultsThe results showed that the expression levels of BRE-AS1 were decreased, while those of miR-106b-5p were increased in ccRCC tissues. BRE-AS1 was found to be closely associated with the prognosis of patients with ccRCC. The expression of BRE-AS1 was inversely correlated with that of miR-106b-5p in tumor tissues. Overexpression of BRE-AS1 led to decreased expression levels of miR-106b-5p and increased methylation of the miR-106b-5p gene, whereas miR-106b-5p did not affect the expression of BRE-AS1. BRE-AS1 inhibited the movement and proliferation of ccRCC cell lines, while miR-106b-5p suppressed the role of BRE-AS1.

conclusionBRE-AS1 may suppress ccRCC by downregulating the expression of miR-106b-5p.

Indexed as

Carcinoma, Renal CellCell MovementDown-RegulationKidney NeoplasmsMicroRNAsRNA, Long NoncodingCell Line, TumorCell ProliferationDNA MethylationFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm InvasivenessMicroRNAsMIRN106 microRNA, humanRNA, Long Noncoding

Identifiers

PMID37530129

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.