Evidence map›Paper›PMID 37529672›Full record

ArticleQRB discovery2021

A multimodal electrochemical approach to measure the effect of zinc on vesicular content and exocytosis in a single cell model of ischemia.

Ying Wang, Chaoyi Gu, Andrew G Ewing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in QRB discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ying WangDepartment of Chemistry and Molecular Biology, University of Gothenburg, 41296 Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-8894-373X
Chaoyi GuDepartment of Chemistry and Molecular Biology, University of Gothenburg, 41296 Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-9237-8956
Andrew G EwingDepartment of Chemistry and Molecular Biology, University of Gothenburg, 41296 Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-2084-0133

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc ion is essential for normal brain function that modulates synaptic activity and neuronal plasticity and it is associated with memory formation. Zinc is considered to be a contributing factor to the pathogenesis of ischemia, but the association between zinc and ischemia on vesicular exocytosis is unclear. In this study, we used a combination of chemical analysis methods and a cell model of ischemia/reperfusion to investigate exocytotic release and vesicular content, as well as the effect of zinc alteration on vesicular exocytosis. Oxygen-glucose deprivation and reperfusion (OGDR) was used as an

Indexed as

Fraction of releaseischemia and zincischemia regulated exocytosisoxygen–glucose deprivation and reperfusionsingle-cell amperometryvesicular content

Identifiers

PMID37529672
PMCPMC10392633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.