ArticleFrontiers in neuroanatomy2023
Reduced cingulate gyrus volume in Cavalier King Charles Spaniels with syringomyelia and neuropathic pain revealed by voxel-based morphometry: a pilot study.
Article in Frontiers in neuroanatomy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- 'Teleonomes in Tatters': The Welfare Costs of Selecting Dogs for Extreme Phenotypes, and the Case for Change.Animals : an open access journal from MDPI · 2026Article
- Investigating gray matter volumes in idiopathic epileptic Border Collies and Greater Swiss Mountain Dogs using voxel-based morphometry.Frontiers in veterinary science · 2026Article
- Subcortical and white matter alterations in canine ventriculomegaly: an observational volumetric and voxel-based-morphometry study.Fluids and barriers of the CNS · 2025Article
- Neuroanatomy of spinal nociception and pain in dogs and cats: a practical review for the veterinary clinician.Frontiers in veterinary science · 2025Review
- CT-based and manual external skull measurements for Chiari-like malformation and syringomyelia in Pomeranians.PloS one · 2024Article
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4 authors.
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Abstract
Objective: Pathomorphological alterations of the central nervous system in dogs, such as syringomyelia and Chiari-like malformation, can cause cranial and cervical hyperesthesia and neuropathic pain. The long-term activity of the pain network can induce functional alteration and eventually even morphological changes in the pain network. This may happen especially in the prefrontal and cingulate cortex, where atrophy of the gray matter (GM) was observed in humans with chronic pain, irrespective of the nature of the pain syndrome. We tested the hypothesis that Cavalier King Charles Spaniels (CKCS) with Chiari-like malformation and associated syringomyelia (SM) and pain show cerebral morphological differences compared to animals without signs of syringomyelia and pain. Methods: Volumetric datasets of 28 different brain structures were analyzed in a retrospective manner, including voxel-based morphometry, using magnetic resonance imaging data obtained from 41 dogs. Results: Volumetric analyses revealed a decrease in GM volumes in the cingulate gyrus (CG) in CKCS with SM and chronic pain when normalized to brain volume. This finding was supported by voxel-based morphometry, which showed a cluster of significance within the CG. Conclusion: GM atrophy in the CG is associated with chronic pain and thus may serve as an objective readout parameter for the diagnosis or treatment of canine pain syndromes.
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