Evidence map›Paper›PMID 37529216›Full record

ReviewMaterials today. Bio2023

Research progress of polyphenols in nanoformulations for antibacterial application.

Chang Liu, Shuhan Dong, Xue Wang, Huiqing Xu, Chang Liu, Xi Yang, Shanli Wu, Xin Jiang, Mujie Kan, Caina Xu

Abstract readReview
In one paragraph

Review in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Forced hemostasisMaterials today. Bio · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Therapeutic Potential of OzonatedPharmaceuticals (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chang LiuDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Shuhan DongDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Xue WangDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Huiqing XuDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Chang LiuDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Xi YangDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Shanli WuDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Xin JiangDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Mujie KanDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.
Caina XuDepartment of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious disease is one of the top 10 causes of death worldwide, especially in low-income countries. The extensive use of antibiotics has led to an increase in antibiotic resistance, which poses a critical threat to human health globally. Natural products such as polyphenolic compounds and their derivatives have been shown the positive therapeutic effects in antibacterial therapy. However, the inherent physicochemical properties of polyphenolic compounds and their derivatives limit their pharmaceutical effects, such as short half-lives, chemical instability, low bioavailability, and poor water solubility. Nanoformulations have shown promising advantages in improving antibacterial activity by controlling the release of drugs and enhancing the bioavailability of polyphenols. In this review, we listed the classification and antibacterial mechanisms of the polyphenolic compounds. More importantly, the nanoformulations for the delivery of polyphenols as the antibacterial agent were summarized, including different types of nanoparticles (NPs) such as polymer-based NPs, metal-based NPs, lipid-based NPs, and nanoscaffolds such as nanogels, nanofibers, and nanoemulsions. At the same time, we also presented the potential biological applications of the nano-system to enhance the antibacterial ability of polyphenols, aiming to provide a new therapeutic perspective for the antibiotic-free treatment of infectious diseases.

Indexed as

Antibacterial activityDrug delivery systemsNanoformulationsPolyphenols

Identifiers

PMID37529216
PMCPMC10387615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.