Evidence map›Paper›PMID 37529105›Full record

ArticleiScience2023

Ebola virus shed glycoprotein is toxic to human T, B, and natural killer lymphocytes.

Luis J Perez-Valencia, Kevin M Vannella, Marcos J Ramos-Benitez, Junfeng Sun, Mones Abu-Asab, David W Dorward, Keytam S Awad, Andrew Platt, Eliana Jacobson, Jason Kindrachuk and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luis J Perez-ValenciaEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Kevin M VannellaEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Marcos J Ramos-BenitezEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Junfeng SunCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Mones Abu-AsabSection of Histopathology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
David W DorwardMicroscopy Unit, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Keytam S AwadCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Andrew PlattEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Eliana JacobsonEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Jason KindrachukLaboratory of Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg MB R3E 0J9, Canada.
Daniel S ChertowEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Clinical and Molecular Features of Ebola Virus DiseaseZIACL009024 · CLC · CLINICAL CENTER · PI CHERTOW, DANIEL S · 2017 to 2025
$0k
Obtaining Samples from Human Subjects to Facilitate Basic, Translational and Clinical ResearchZIACL009029 · CLC · CLINICAL CENTER · PI SOLOMON, MICHAEL · 2018 to 2025
$0k
6 · The paper itself

Abstract

Lymphocyte depletion is a distinctive feature of Ebola virus (EBOV) disease. The ectodomain of EBOV glycoprotein (GP) is cleaved off the surface of infected cells into circulation as shed GP. To test the hypothesis that shed GP induces lymphocyte death, we cultured primary human B, NK, or T cells with shed GP

Indexed as

Cell biologyImmunologyMolecular biologyVirology

Identifiers

PMID37529105
PMCPMC10387567

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.