Hematochezia caused by tandospirone in a patient with major depressive disorder and anxious distress: a case report.

Xingmei Jiang, Zhongrui Ma, Zhixiong Li, Ying Ou, Zhenhua Luo, Zhe Li

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Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Xingmei JiangMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Zhongrui MaGeriatric Diseases Institute of Chengdu, Department of Psychosomatics, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.

Zhixiong LiThe Third Department of Clinical Psychology, Karamay Municipal People's Hospital, Karamay, Xinjiang, China.

Ying OuMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Zhenhua LuoThe First Affiliated Hospital of Traditional Chinese Medicine, Chengdu Medical College, Chengdu, Sichuan, China.

Zhe LiMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Major depressive disorder (MDD) with anxious distress is a relatively common condition that is often associated with a poor treatment response. In order to enhance the effectiveness of MDD treatment, 5-HT1A agonists like tandospirone are often prescribed in conjunction with antidepressants. While it is known that antidepressants can increase the risk of bleeding, whether tandospirone poses a similar risk remains uncertain. Case presentation: We presented the case of a 55-year-old Chinese woman diagnosed with MDD and anxious distress. After receiving various types of antidepressants, she experienced hematochezia following the administration of tandospirone, sertraline, and agomelatine. The occurrence of hematochezia ceased after tandospirone was discontinued. The patient was subsequently discharged with a treatment regime consisting of sertraline and agomelatine. During the 1-month follow-up, she reported no hematochezia. Conclusion: Tandospirone may potentially increase the risk of hematochezia in patients with MDD and anxious distress.

Indexed as

antidepressantanxious distresscase reportdepressive disorderhematocheziatandospirone

Identifiers

PMID37529069

DOI10.3389/fpsyt.2023.1209354

PMCPMC10387755

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