Evidence map›Paper›PMID 37528404›Full record

ArticleBMC musculoskeletal disorders2023

Evidence for an association of serum microanalytes and myofascial pain syndrome.

Aishwarya Pradeep, Aybike Birerdinc, Travis Branigan, Vy Phan, Hailey Morris, Jay Shah, Secili DeStefano, Siddhartha Sikdar, John Srbely, Dinesh Kumbhare and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Aishwarya PradeepRehabilitation Medicine Department, Clinical Center, National Institutes of Health, 9000 Rockville Pike, , Bethesda, MD, 20892, USA.
Aybike BirerdincCollege of Science, George Mason University, 4400 University Drive, Fairfax, VA, 22032, USA.
Travis BraniganDepartment of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Vy PhanRehabilitation Medicine Department, Clinical Center, National Institutes of Health, 9000 Rockville Pike, , Bethesda, MD, 20892, USA.
Hailey MorrisRehabilitation Medicine Department, Clinical Center, National Institutes of Health, 9000 Rockville Pike, , Bethesda, MD, 20892, USA.
Jay ShahRehabilitation Medicine Department, Clinical Center, National Institutes of Health, 9000 Rockville Pike, , Bethesda, MD, 20892, USA.
Secili DeStefanoCollege of Public Health, George Mason University, 4400 University Drive, Fairfax, VA, 22030, USA.
Siddhartha SikdarVolgenau School, George Mason University, 4400 University Drive, Fairfax, VA, 22032, USA.
John SrbelyDepartment of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Dinesh KumbhareDepartment of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.
Antonio SteccoDepartment of Physical Medicine and Rehabilitation, New York University Langone Medical Center, 550 First Avenue, New York, NY, 10016, USA.
James PaikMedicine Service Line, Inova Health System, 3300 Gallows Rd, Falls Church, VA, 22042, USA.
Lynn H GerberCollege of Public Health, George Mason University, 4400 University Drive, Fairfax, VA, 22030, USA. Ngerber1@gmu.edu.
National Institutes of Health Clinical Center · USGeorge Mason University · USInova Health System · USUniversity of Guelph · CANYU Langone Health · USUniversity of Toronto · CA

Funding

Multimodal imaging biomarkers for investigating fascia, muscle and vasculature in myofascial pain.R61AT012286 · NCCIH · GEORGE MASON UNIVERSITY · PI SIKDAR, SIDDHARTHA · 2022 to 2022
$1.5M
NCCIH NIH HHS R61 AT012286
6 · The paper itself

Abstract

backgroundMyofascial Pain Syndrome (MPS) is a common pain disorder. Diagnostic criteria include physical findings which are often unreliable or not universally accepted. A precise biosignature may improve diagnosis and treatment effectiveness. The purpose of this study was to assess whether microanalytic assays significantly correlate with characteristic clinical findings in people with MPS.

methodsThis descriptive, prospective study included 38 participants (25 women) with greater than 3 months of myofascial pain in the upper trapezius. Assessments were performed at a university laboratory. The main outcome measures were the Beighton Index, shoulder range of motion, strength asymmetries and microanalytes: DHEA, Kynurenine, VEGF, interleukins (IL-1b, IL-2, IL-4, IL-5, IL-7, IL-8, IL-13), growth factors (IGF-1, IGF2, G-CSF, GM-CSF), MCP-1, MIP-1b, BDNF, Dopamine, Noradrenaline, NPY, and Acetylcholine. Mann-Whitney test and Spearman's multivariate correlation were applied for all variables. The Spearman's analysis results were used to generate a standard correlation matrix and heat map matrix.

resultsMean age of participants was 32 years (20-61). Eight (21%) had widespread pain (Widespread Pain Index ≥ 7). Thirteen (34%) had MPS for 1-3 years, 14 (37%) 3-10 years, and 11 (29%) for > 10 years. The following showed strong correlations: IL1b,2,4,5,7,8; GM-CSF and IL 2,4,5,7; between DHEA and BDNF and between BDNF and Kynurenine, NPY and acetylcholine. The heat map analysis demonstrated strong correlations between the Beighton Index and IL 5,7, GM-CSF, DHEA. Asymmetries of shoulder and cervical spine motion and strength associated with select microanalytes.

conclusionCytokine levels significantly correlate with selected clinical assessments. This indirectly suggests possible biological relevance for understanding MPS. Correlations among some cytokine clusters; and DHEA, BDNF kynurenine, NPY, and acetylcholine may act together in MPS. These findings should be further investigated for confirmation that link these microanalytes with select clinical findings in people with MPS.

Indexed as

FibromyalgiaMyofascial Pain SyndromesAcetylcholineAdultBrain-Derived Neurotrophic FactorCytokinesDehydroepiandrosteroneFemaleGranulocyte-Macrophage Colony-Stimulating FactorHumansKynurenineMiddle AgedPainProspective StudiesYoung AdultAcetylcholineBrain-Derived Neurotrophic FactorCytokinesDehydroepiandrosteroneGranulocyte-Macrophage Colony-Stimulating FactorKynurenineCytokinesMyofascial Pain SyndromeSerum Microanalytes

Identifiers

PMID37528404
PMCPMC10391753
OpenAlexW4385445407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.