Evidence map›Paper›PMID 37528297›Full record

ArticleHerz2024

Is lysosomal acid lipase activity associated with the presence and severity of coronary artery disease?

Emrullah Kızıltunç, Sabire Gökalp, Gürsel Biberoğlu, Yakup Yalçın, Burcu Cihan, Rıdvan M Öktem, Aslı İnci, Leyla Tümer, Mehmet R Yalçın, Adnan Abacı

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In one paragraph

Article in Herz, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Emrullah KızıltunçDepartment of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey. e.kiziltunc@gmail.com.ORCID http://orcid.org/0000-0002-8152-9680
Sabire GökalpDepartment of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0001-5383-5632
Gürsel BiberoğluDepartment of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0001-9469-993X
Yakup YalçınDepartment of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey.ORCID http://orcid.org/0000-0002-8034-5847
Burcu CihanDepartment of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey.ORCID http://orcid.org/0000-0002-3697-7919
Rıdvan M ÖktemDepartment of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0002-9882-2883
Aslı İnciDepartment of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0002-0561-2060
Leyla TümerDepartment of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0002-7831-3184
Mehmet R YalçınDepartment of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey.ORCID http://orcid.org/0000-0001-5585-1505
Adnan AbacıDepartment of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey.ORCID http://orcid.org/0000-0001-8538-4733
Gazi University · TR

Funding

Gazi Üniversitesi 5951
6 · The paper itself

Abstract

backgroundLipid metabolism is considerably complex and there can be many critical steps in atherogenesis. The association between lysosomal acid lipase (LAL) activity and coronary artery disease (CAD) has not been elucidated in detail. We aimed to evaluate the association between LAL activity with the presence and severity of CAD in patients who are seen in daily clinical practice.

methodsPatients who underwent coronary angiography were divided into groups according to the angiography results. Syntax scores and Gensini scores were calculated. The LAL activity was measured from dried blood spots.

resultsMedian LAL activity values were similar in all study groups (normal coronary arteries: 0.40 nmol/punch/h; non-obstructive CAD: 0.44 nmol/punch/h; obstructive chronic CAD: 0.40 nmol/punch/h; obstructive acute coronary syndrome: 0.48 nmol/punch/h) and there was no correlation between coronary atherosclerotic burden and LAL activity (correlation coefficients Syntax score and LAL: -0.032; Gensini score and LAL: -0.030). In addition, no relationship between serum lipid levels and LAL activity was detected.

conclusionThe presence of CAD and its severity is not associated with the LAL activity in patients encountered in daily clinical practice.

Indexed as

Acute Coronary SyndromeCoronary Artery DiseaseCoronary AngiographyHumansSeverity of Illness IndexSterol EsteraseSterol EsteraseAcid lipase activityAtherosclerotic heart diseaseCoronary angiographyGensini scoreSyntax score

Identifiers

PMID37528297
OpenAlexW4385444241

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.