Evidence map›Paper›PMID 37528264›Full record

ArticleBreast cancer research and treatment2023

High neuroticism is associated with common late adverse effects in a nationwide sample of long-term breast cancer survivors.

Alv A Dahl, Solveig K Smedsland, Kathrine F Vandraas, Synne K Bøhn, Ragnhild S Falk, Cecilie E Kiserud, Kristin V Reinertsen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07739784 (Personality Traits and Their Relation to Ocular Adverse Effects From Glaucoma Medications), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07739784 recruitingnot on this mapstarted 2026, after this paper: background citation

Personality Traits and Their Relation to Ocular Adverse Effects From Glaucoma Medications

TypeobservationalSponsorMcGill University Health Centre/Research Institute of the McGill University Health CentreRan2026 to 2027Enrolled352ConditionsGlaucomaArmsNo Interventions
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alv A DahlNational Advisory Unit for Late Effects After Cancer Treatment, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Nydalen, P.O. Box 4953, 0424, Oslo, Norway. alvandreas@msn.com.ORCID http://orcid.org/0000-0002-6849-2756
Solveig K SmedslandNational Advisory Unit for Late Effects After Cancer Treatment, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Nydalen, P.O. Box 4953, 0424, Oslo, Norway.
Kathrine F VandraasNational Advisory Unit for Late Effects After Cancer Treatment, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Nydalen, P.O. Box 4953, 0424, Oslo, Norway.
Synne K BøhnNational Advisory Unit for Late Effects After Cancer Treatment, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Nydalen, P.O. Box 4953, 0424, Oslo, Norway.
Ragnhild S FalkOslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway.
Cecilie E KiserudNational Advisory Unit for Late Effects After Cancer Treatment, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Nydalen, P.O. Box 4953, 0424, Oslo, Norway.
Kristin V ReinertsenNational Advisory Unit for Late Effects After Cancer Treatment, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Nydalen, P.O. Box 4953, 0424, Oslo, Norway.

Funding

Brystkreftforeningen 197255
6 · The paper itself

Abstract

purposeNeuroticism is a basic personality trait characterized by negative emotions triggered by stress such as a breast cancer diagnosis and its treatment. Due to lack of relevant research, the purpose of this study was to examine if high neuroticism is associated with seven common late adverse effects (LAEs) in long-term (≥ 5 years) breast cancer survivors (BCSs).

methodsAll female Norwegian BCSs aged 20-65 years when diagnosed with stage I-III breast cancer in 2011 or 2012 were invited to a questionnaire study in 2019 (N = 2803), of whom 48% participated (N = 1355). Neuroticism was self-rated using the abridged version of the Eysenck Personality Questionnaire, and scores dichotomized into high and low neuroticism. LAEs were defined by categorization of ratings on the EORTC QLQ-C30 (cognitive function, pain, and sleep problems) and QLQ-BR23 (arm problems) questionnaires, and categorizations of scale scores on mental distress, fatigue, and neuropathy. Associations between high neuroticism and LAEs were explored using multivariate logistic regression analyses.

resultsHigh neuroticism was found in 40% (95%CI 37-42%) of BCSs. All LAEs were significantly more common among BCSs with high compared to low neuroticism. In multivariable analyses, high neuroticism was positively associated with all LAEs except neuropathy. Systemic treatment, somatic comorbidity, and not being in paid work were also significantly associated with all LAEs.

conclusionsHigh neuroticism is prevalent and associated with increased risks of LAEs among BCSs. Identification of high neuroticism could improve the follow-up care of BCSs as effective interventions for the condition exist.

Indexed as

Breast NeoplasmsCancer SurvivorsMental DisordersFemaleHumansNeuroticismQuality of LifeSurveys and QuestionnairesBreast cancer survivorsHealth-related quality of lifeLate adverse effectsNation-wide cross-sectional studyNeuroticism

Identifiers

PMID37528264
PMCPMC10504095

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.